Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix
Noise in the immunohematological investigations can be described as a false reactivity of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. These false-positive reactions can cause confusion d...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_97_23 |
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| _version_ | 1841554825859301376 |
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| author | Durba Biswas Debapriya Basu Mahua Reddy Suvro Sankha Datta |
| author_facet | Durba Biswas Debapriya Basu Mahua Reddy Suvro Sankha Datta |
| author_sort | Durba Biswas |
| collection | DOAJ |
| description | Noise in the immunohematological investigations can be described as a false reactivity of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. These false-positive reactions can cause confusion during the cross-matching and RBC antibody screening and may result in delays in patient transfusion. Although these antibodies are predominantly clinically insignificant, proper laboratory work-up is indicated to avoid misidentification of a clinically significant antibody as a noise. In this report, we describe the three rare cases where the reactivity was found against the ingredients of the column matrix (glass beads). It is imperative that such reactivity is recognized and resolved during the investigation of blood group discrepancies, positive RBC antibody screens and in cases of positive cross-matches. |
| format | Article |
| id | doaj-art-79f5cf0f969f4791b6d6eea698ee42e4 |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-79f5cf0f969f4791b6d6eea698ee42e42025-01-08T09:11:58ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652024-12-0118234134410.4103/ajts.ajts_97_23Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrixDurba BiswasDebapriya BasuMahua ReddySuvro Sankha DattaNoise in the immunohematological investigations can be described as a false reactivity of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. These false-positive reactions can cause confusion during the cross-matching and RBC antibody screening and may result in delays in patient transfusion. Although these antibodies are predominantly clinically insignificant, proper laboratory work-up is indicated to avoid misidentification of a clinically significant antibody as a noise. In this report, we describe the three rare cases where the reactivity was found against the ingredients of the column matrix (glass beads). It is imperative that such reactivity is recognized and resolved during the investigation of blood group discrepancies, positive RBC antibody screens and in cases of positive cross-matches.https://journals.lww.com/10.4103/ajts.ajts_97_23antibody screeningblood group discrepancyfalse-positive reactionsglass beadspanreactivity |
| spellingShingle | Durba Biswas Debapriya Basu Mahua Reddy Suvro Sankha Datta Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix Asian Journal of Transfusion Science antibody screening blood group discrepancy false-positive reactions glass beads panreactivity |
| title | Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix |
| title_full | Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix |
| title_fullStr | Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix |
| title_full_unstemmed | Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix |
| title_short | Red cell antibodies or noise? A case series on reactivity against the ingredients in column matrix |
| title_sort | red cell antibodies or noise a case series on reactivity against the ingredients in column matrix |
| topic | antibody screening blood group discrepancy false-positive reactions glass beads panreactivity |
| url | https://journals.lww.com/10.4103/ajts.ajts_97_23 |
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