Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project
To date, no retrospective or real-world studies have comprehensively examined the interactions between direct-acting antivirals (DAAs) and widely used medications such as novel oral anticoagulant, statins, and antihypertensive agents. However, clinical experience from key opinion leaders may guide...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-11-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/ijm/article/view/1846 |
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| author | Ivan Gentile Giancarlo Agnelli Angelo Avogaro Claudio Borghi Alessia Ciancio Ernesto Claar Patrizio Pasqualetti Pasquale Perrone Filardi |
| author_facet | Ivan Gentile Giancarlo Agnelli Angelo Avogaro Claudio Borghi Alessia Ciancio Ernesto Claar Patrizio Pasqualetti Pasquale Perrone Filardi |
| author_sort | Ivan Gentile |
| collection | DOAJ |
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To date, no retrospective or real-world studies have comprehensively examined the interactions between direct-acting antivirals (DAAs) and widely used medications such as novel oral anticoagulant, statins, and antihypertensive agents. However, clinical experience from key opinion leaders may guide physicians in managing these interactions in patients undergoing DAA treatment. This study aims to elucidate the interactions between DAAs and commonly prescribed drugs in patients with prevalent comorbidities (e.g., type II diabetes, hypertension, and dyslipidemia), with a particular focus on those receiving polytherapy with cardiovascular drugs while undergoing DAA treatment for hepatitis C. The clinicians’ experience was combined with input from a qualified expert panel using a Consensus Delphi approach. The findings of this study offer essential and practical recommendations that can be readily applied in everyday clinical practice, helping physicians in managing hepatitis C virus patients undergoing DAA therapy.
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| format | Article |
| id | doaj-art-79ef50596dd640da94e5784e129c6c60 |
| institution | Kabale University |
| issn | 1877-9344 1877-9352 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj-art-79ef50596dd640da94e5784e129c6c602024-11-26T02:09:59ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522024-11-0118410.4081/itjm.2024.1846Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus projectIvan Gentile0Giancarlo Agnelli1Angelo Avogaro2Claudio Borghi3Alessia Ciancio4Ernesto Claar5Patrizio Pasqualetti6Pasquale Perrone Filardi7Department of Clinical Medicine and Surgery, Federico II University of NaplesInternal, Vascular and Emergency Medicine-Stroke Unit, University of PerugiaSection of Diabetes and Metabolic Diseases, Department of Medicine, University of PaduaInternal Medicine, Department of Medical and Surgical Sciences, Policlinic S. Orsola-Malpighi, University of BolognaGastroenterology Unit, Department of Internal Medicine, Città della Salute e della Scienza di Torino, University of TurinLiver Unit, Ospedale Evangelico Betania, NaplesSection of Health Statistics and Biometry, Department of Public Health and Infectious Diseases, Faculty of Pharmacy and Medicine, Sapienza University of RomeDepartment of Advanced Biomedical Sciences, Federico II University of Naples To date, no retrospective or real-world studies have comprehensively examined the interactions between direct-acting antivirals (DAAs) and widely used medications such as novel oral anticoagulant, statins, and antihypertensive agents. However, clinical experience from key opinion leaders may guide physicians in managing these interactions in patients undergoing DAA treatment. This study aims to elucidate the interactions between DAAs and commonly prescribed drugs in patients with prevalent comorbidities (e.g., type II diabetes, hypertension, and dyslipidemia), with a particular focus on those receiving polytherapy with cardiovascular drugs while undergoing DAA treatment for hepatitis C. The clinicians’ experience was combined with input from a qualified expert panel using a Consensus Delphi approach. The findings of this study offer essential and practical recommendations that can be readily applied in everyday clinical practice, helping physicians in managing hepatitis C virus patients undergoing DAA therapy. https://www.italjmed.org/ijm/article/view/1846Direct-acting antiviralshepatitis Cnovel oral anticoagulantsstatinshypertension therapy |
| spellingShingle | Ivan Gentile Giancarlo Agnelli Angelo Avogaro Claudio Borghi Alessia Ciancio Ernesto Claar Patrizio Pasqualetti Pasquale Perrone Filardi Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project Italian Journal of Medicine Direct-acting antivirals hepatitis C novel oral anticoagulants statins hypertension therapy |
| title | Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project |
| title_full | Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project |
| title_fullStr | Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project |
| title_full_unstemmed | Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project |
| title_short | Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project |
| title_sort | pharmacological interactions in novel oral anticoagulants statins and hypertension drugs in patients treated with direct acting antivirals for hepatitis c a delphi consensus project |
| topic | Direct-acting antivirals hepatitis C novel oral anticoagulants statins hypertension therapy |
| url | https://www.italjmed.org/ijm/article/view/1846 |
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