Differentiation therapy targeting the stalled epigenetic developmental programs in pediatric high-grade gliomas

Differentiation therapy targeting the stalled epigenetic developmental programs in pediatric high-grade gliomas

Pediatric high-grade gliomas (pHGGs) are the most common brain malignancies in children and are characterized by blocked differentiation. The epigenetic landscape of pHGGs, particularly the H3K27-altered and H3G34-mutant subtypes, suggests these tumors may be particularly susceptible to strategies t...

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Bibliographic Details
Main Authors: Wang Xiang, Xiaolin Zhang, Minhai Dong, Lijun Wan, Bin Zhang, Feng Wan
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
Pediatric high-grade glioma
Differentiation therapy
Epigenetic regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000246
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