AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice

AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice

Abstract Bone cancer pain (BCP) is a common clinical problem in cancer patients. The plasticity of excitatory neurons within the spinal dorsal horn plays a significant role in the development of BCP. This study explored the roles of absent in melanoma 2 (AIM2) and stimulator of interferon gene (STIN...

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Bibliographic Details
Main Authors: Linhan Wang, Xueqin Xu, Shanchun Su, Biyun Li, Kunyu Zhang, Xiuqin Yu, Yangqiao Xiao, Shuangshuang Lu, Zihao Lu, Yanqiong Wu, Changbin Ke
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
AIM2
STING
GluN1
Spinal cord
Bone cancer pain
Online Access:https://doi.org/10.1038/s41598-024-83027-w
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