Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage
Abstract Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhe...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86443-8 |
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| author | Tomas Rohan Barbora Cechova Peter Matkulcik Matej Straka Jan Zavadil Michal Eid Michal Uher Marek Dostal Tomas Andrasina |
| author_facet | Tomas Rohan Barbora Cechova Peter Matkulcik Matej Straka Jan Zavadil Michal Eid Michal Uher Marek Dostal Tomas Andrasina |
| author_sort | Tomas Rohan |
| collection | DOAJ |
| description | Abstract Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhepatic biliary drainage (PTBD) and to develop a simple scoring system predicting survival from PTBD insertion. This single-centre retrospective study included 175 consecutive patients undergoing PTBD for extrahepatic CCA (perihilar and distal). Prognostic factors affecting survival of patients with CCA treated with PTBD were analysed. A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). Multivariate analysis identified two significant risk factors for 3-month mortality: mass-forming tumors and bilirubin levels exceeding 185 µmol/L. A simple scoring system was developed to predict 3-month mortality after PTBD in patients with advanced CCA, demonstrating 86.3% negative predictive value and 43.2% positive predictive value. |
| format | Article |
| id | doaj-art-799cffb40e9c467b83386d14195dc065 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-799cffb40e9c467b83386d14195dc0652025-01-19T12:22:32ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86443-8Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainageTomas Rohan0Barbora Cechova1Peter Matkulcik2Matej Straka3Jan Zavadil4Michal Eid5Michal Uher6Marek Dostal7Tomas Andrasina8Department of Radiology and Nuclear Medicine, University Hospital BrnoDepartment of Radiology and Nuclear Medicine, University Hospital BrnoDepartment of Radiology and Nuclear Medicine, University Hospital BrnoMedical Faculty, Masaryk UniversityMedical Faculty, Masaryk UniversityMedical Faculty, Masaryk UniversityMasaryk Memorial Cancer InstituteDepartment of Radiology and Nuclear Medicine, University Hospital BrnoDepartment of Radiology and Nuclear Medicine, University Hospital BrnoAbstract Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhepatic biliary drainage (PTBD) and to develop a simple scoring system predicting survival from PTBD insertion. This single-centre retrospective study included 175 consecutive patients undergoing PTBD for extrahepatic CCA (perihilar and distal). Prognostic factors affecting survival of patients with CCA treated with PTBD were analysed. A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). Multivariate analysis identified two significant risk factors for 3-month mortality: mass-forming tumors and bilirubin levels exceeding 185 µmol/L. A simple scoring system was developed to predict 3-month mortality after PTBD in patients with advanced CCA, demonstrating 86.3% negative predictive value and 43.2% positive predictive value.https://doi.org/10.1038/s41598-025-86443-8Percutaneous transhepatic biliary drainageBiliary malignancyBiliary stenosisMetal stentPrognostic factorsScoring system |
| spellingShingle | Tomas Rohan Barbora Cechova Peter Matkulcik Matej Straka Jan Zavadil Michal Eid Michal Uher Marek Dostal Tomas Andrasina Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage Scientific Reports Percutaneous transhepatic biliary drainage Biliary malignancy Biliary stenosis Metal stent Prognostic factors Scoring system |
| title | Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage |
| title_full | Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage |
| title_fullStr | Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage |
| title_full_unstemmed | Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage |
| title_short | Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage |
| title_sort | prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage |
| topic | Percutaneous transhepatic biliary drainage Biliary malignancy Biliary stenosis Metal stent Prognostic factors Scoring system |
| url | https://doi.org/10.1038/s41598-025-86443-8 |
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