ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE
Despite availability of many antifungal agents, antifungal clinical resistance occurs, perhaps as a result of an infecting organism found to be resistant in vitro to one or more antifungals tested. Thus, antifungal susceptibility testing (AFST) results, if timely generated by the clinical microbiolo...
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Format: | Article |
Language: | English |
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PAGEPress Publications
2014-04-01
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Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/1367 |
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author | Brunella Posteraro Riccardo Torelli Elena De Carolis Patrizia Posteraro Maurizio Sanguinetti |
author_facet | Brunella Posteraro Riccardo Torelli Elena De Carolis Patrizia Posteraro Maurizio Sanguinetti |
author_sort | Brunella Posteraro |
collection | DOAJ |
description | Despite availability of many antifungal agents, antifungal clinical resistance occurs, perhaps as a result of an infecting organism found to be resistant in vitro to one or more antifungals tested. Thus, antifungal susceptibility testing (AFST) results, if timely generated by the clinical microbiology and communicated to clinicians, can aid them in the therapeutic decision making, especially for difficult-to-treat invasive candidiasis and aspergillosis. Although recently refined AFST methods are commercially available to allow a close antifungal resistance surveillance in many clinical setting, novel assays, relying on short-time antifungal drug exposure of fungal isolates, are upcoming tools for AFST. Based on emerging technologies such as flow cytometry, MALDI-TOF mass spectrometry, and isothermal microcalorimetry, these assays could provide a reliable means for quicker and sensitive assessment of AFST. |
format | Article |
id | doaj-art-7975afd6e38b4bea8384c4dd9f864a8d |
institution | Kabale University |
issn | 2035-3006 |
language | English |
publishDate | 2014-04-01 |
publisher | PAGEPress Publications |
record_format | Article |
series | Mediterranean Journal of Hematology and Infectious Diseases |
spelling | doaj-art-7975afd6e38b4bea8384c4dd9f864a8d2025-01-02T11:13:55ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-04-0161e2014030e201403010.4084/mjhid.2014.0301127ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVEBrunella Posteraro0Riccardo Torelli1Elena De Carolis2Patrizia Posteraro3Maurizio Sanguinetti4Catholic University. Public HealthCatholic University. MicrobiologyCatholic University. MicrobiologyClinical Laboratory, Ospedale San Carlo, RomeCatholic University. MicrobiologyDespite availability of many antifungal agents, antifungal clinical resistance occurs, perhaps as a result of an infecting organism found to be resistant in vitro to one or more antifungals tested. Thus, antifungal susceptibility testing (AFST) results, if timely generated by the clinical microbiology and communicated to clinicians, can aid them in the therapeutic decision making, especially for difficult-to-treat invasive candidiasis and aspergillosis. Although recently refined AFST methods are commercially available to allow a close antifungal resistance surveillance in many clinical setting, novel assays, relying on short-time antifungal drug exposure of fungal isolates, are upcoming tools for AFST. Based on emerging technologies such as flow cytometry, MALDI-TOF mass spectrometry, and isothermal microcalorimetry, these assays could provide a reliable means for quicker and sensitive assessment of AFST.http://www.mjhid.org/index.php/mjhid/article/view/1367Fungal infections, Antifungal agentsSusceptibility testing |
spellingShingle | Brunella Posteraro Riccardo Torelli Elena De Carolis Patrizia Posteraro Maurizio Sanguinetti ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE Mediterranean Journal of Hematology and Infectious Diseases Fungal infections, Antifungal agents Susceptibility testing |
title | ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE |
title_full | ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE |
title_fullStr | ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE |
title_full_unstemmed | ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE |
title_short | ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE |
title_sort | antifungal susceptibility testing current role from the clinical laboratory perspective |
topic | Fungal infections, Antifungal agents Susceptibility testing |
url | http://www.mjhid.org/index.php/mjhid/article/view/1367 |
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