The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide
Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide is a new selective type II carbonic anhydrase inhibitor with local action through instillation into the eyes. For a complete pharmacokinetic study of this drug, it is necessary to detect and synthesize its metabolites for their syst...
Saved in:
Main Authors: | Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov |
---|---|
Format: | Article |
Language: | English |
Published: |
Belgorod National Research University
2024-11-01
|
Series: | Research Results in Pharmacology |
Subjects: | |
Online Access: | https://rrpharmacology.ru/index.php/journal/article/view/498 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma
by: Alexander L. Khokhlov, et al.
Published: (2024-12-01) -
Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents
by: Tulika Anthwal, et al.
Published: (2025-02-01) -
Purification and characterization of lipase from Bacillus subtilis kubt4 for biodiesel production
by: Parveen Nadaf, et al.
Published: (2025-01-01) -
Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB
by: P. S. Rao, et al.
Published: (2024-02-01) -
Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats
by: Sara Amiranda, et al.
Published: (2025-02-01)