Associations between serum cystatin C and fall reports in an Elderly population
Abstract Fall is common in the elderly, and chronic kidney disease is considered a major risk factor. Serum creatinine (Cre) and cystatin C (Cys C) are commonly used biomarkers for renal function, while the ratio of Cre to Cys C, known as the sarcopenia index (SI), provides insights into muscle heal...
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Nature Portfolio
2024-10-01
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| Online Access: | https://doi.org/10.1038/s41598-024-77138-7 |
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| author | Jing Han Ruiyun Wang Lijuan Bai Yun Liu Man Liao Liting Zhang Lihua Liu Benling Qi |
| author_facet | Jing Han Ruiyun Wang Lijuan Bai Yun Liu Man Liao Liting Zhang Lihua Liu Benling Qi |
| author_sort | Jing Han |
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| description | Abstract Fall is common in the elderly, and chronic kidney disease is considered a major risk factor. Serum creatinine (Cre) and cystatin C (Cys C) are commonly used biomarkers for renal function, while the ratio of Cre to Cys C, known as the sarcopenia index (SI), provides insights into muscle health. This study investigates the relationships between Cre, Cys C, estimated glomerular filtration rates (eGFR), SI, and self-reported falls using National Health and Nutrition Examination Survey (NHANES) data. We included 4,272 older adults with eGFR > 30mL/min/1.73m2 from NHANES (1999 to 2004) and divided them into the fall and non-fall groups based on the questionnaires. Correlations were assessed using restricted cubic spline, weighted generalized linear regression models. Multi-factor logistic regression analysis identified serum Cys C as significantly associated with falls (all participants: OR 1.16, 95% CI: 1.09 to 1.23, p < 0.001; participants with eGFR > 75 mL/min/1.73m2: OR 1.17, 95% CI: 1.05 to 1.30, p < 0.001,). In contrast, Cre and eGFR were not significant after adjustments; SI showed marginal significance (p = 0.045). Cys C is significantly associated with fall risk in older adults, demonstrating a positive linear relationship with self-reported falls. |
| format | Article |
| id | doaj-art-795a353b51734dab93f3a05fbc4afb21 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-795a353b51734dab93f3a05fbc4afb212024-12-01T12:25:45ZengNature PortfolioScientific Reports2045-23222024-10-011411910.1038/s41598-024-77138-7Associations between serum cystatin C and fall reports in an Elderly populationJing Han0Ruiyun Wang1Lijuan Bai2Yun Liu3Man Liao4Liting Zhang5Lihua Liu6Benling Qi7Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Fall is common in the elderly, and chronic kidney disease is considered a major risk factor. Serum creatinine (Cre) and cystatin C (Cys C) are commonly used biomarkers for renal function, while the ratio of Cre to Cys C, known as the sarcopenia index (SI), provides insights into muscle health. This study investigates the relationships between Cre, Cys C, estimated glomerular filtration rates (eGFR), SI, and self-reported falls using National Health and Nutrition Examination Survey (NHANES) data. We included 4,272 older adults with eGFR > 30mL/min/1.73m2 from NHANES (1999 to 2004) and divided them into the fall and non-fall groups based on the questionnaires. Correlations were assessed using restricted cubic spline, weighted generalized linear regression models. Multi-factor logistic regression analysis identified serum Cys C as significantly associated with falls (all participants: OR 1.16, 95% CI: 1.09 to 1.23, p < 0.001; participants with eGFR > 75 mL/min/1.73m2: OR 1.17, 95% CI: 1.05 to 1.30, p < 0.001,). In contrast, Cre and eGFR were not significant after adjustments; SI showed marginal significance (p = 0.045). Cys C is significantly associated with fall risk in older adults, demonstrating a positive linear relationship with self-reported falls.https://doi.org/10.1038/s41598-024-77138-7Serum cystatin Cserum creatinineeGFRsarcopenia indexfallolder adults |
| spellingShingle | Jing Han Ruiyun Wang Lijuan Bai Yun Liu Man Liao Liting Zhang Lihua Liu Benling Qi Associations between serum cystatin C and fall reports in an Elderly population Scientific Reports Serum cystatin C serum creatinine eGFR sarcopenia index fall older adults |
| title | Associations between serum cystatin C and fall reports in an Elderly population |
| title_full | Associations between serum cystatin C and fall reports in an Elderly population |
| title_fullStr | Associations between serum cystatin C and fall reports in an Elderly population |
| title_full_unstemmed | Associations between serum cystatin C and fall reports in an Elderly population |
| title_short | Associations between serum cystatin C and fall reports in an Elderly population |
| title_sort | associations between serum cystatin c and fall reports in an elderly population |
| topic | Serum cystatin C serum creatinine eGFR sarcopenia index fall older adults |
| url | https://doi.org/10.1038/s41598-024-77138-7 |
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