Hyperprogressive disease induced by PD-1 inhibitor monotherapy in lung adenocarcinoma with HER2 exon 20 insertion: report of two cases and review of literature

Hyperprogressive disease induced by PD-1 inhibitor monotherapy in lung adenocarcinoma with HER2 exon 20 insertion: report of two cases and review of literature

Abstract Monotherapy with anti-programmed cell death protein 1 (PD-1) monoclonal antibody has been approved for the treatment of advanced non-small cell lung cancer with positive programmed cell death-ligand 1 (PD-L1) expression and oncogene wild type, which revealed survival benefit compared with c...

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Bibliographic Details
Main Authors: Guangjian Yang, Linyan Tian, Yan Wang
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Hyperprogressive disease
PD-1 inhibitor
HER2
Exon 20 insertion
Non-small cell lung cancer
Case report
Online Access:https://doi.org/10.1007/s12672-025-01749-3
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