Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers
Objective: This study investigates the prognostic significance of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score and Prognostic Nutritional Index (PNI) in metastatic head and neck cancers. Methods: Retrospective analysis was conducted on data obtained from January 2014 to June 2022 for 68 pa...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958424007553 |
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| author | Yakup Duzkopru Abdulkadir Kocanoglu Mehmet Yigitbay Ozlem Dogan Hayriye Sahinli Dogan Yazilitas |
| author_facet | Yakup Duzkopru Abdulkadir Kocanoglu Mehmet Yigitbay Ozlem Dogan Hayriye Sahinli Dogan Yazilitas |
| author_sort | Yakup Duzkopru |
| collection | DOAJ |
| description | Objective: This study investigates the prognostic significance of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score and Prognostic Nutritional Index (PNI) in metastatic head and neck cancers. Methods: Retrospective analysis was conducted on data obtained from January 2014 to June 2022 for 68 patients using rigorous statistical methods. HALP and PNI scores, derived from routine laboratory parameters, were categorized into low and high groups using respective median values. Prognostic significance was determined through Kaplan–Meier survival analyses and Cox proportional hazards regression using IBM SPSS Statistics. Results: Of the 68 patients (80.9% male, median age 57), 39 (57.4%) had laryngeal cancer. When stratified by low and high HALP scores, the median overall survival (OS) was 5.9 and 16.4 months, respectively (P < 0.001), while the median progression-free survival (PFS) was 5.7 months and 8.2 months, respectively (P: 0.016). In the low and high PNI score groups, the median OS was 7 and 13.2 months (P < 0.001), with median PFS of 5.6 months and 8.2 months (P: 0.002), respectively. In the multivariate analysis, while the HALP score did not reach statistical significance in terms of PFS, the PNI score and age groups were found to be statistically significant. In terms of OS, higher HALP score and PNI scores were significantly associated with longer OS. Conclusion: In this study, the HALP score and PNI score were found to be a prognostic factor in patients with metastatic head and neck cancer. |
| format | Article |
| id | doaj-art-79221193b0734b2290d9c6f1be5e64d4 |
| institution | Kabale University |
| issn | 1015-9584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj-art-79221193b0734b2290d9c6f1be5e64d42024-11-30T07:09:04ZengElsevierAsian Journal of Surgery1015-95842024-12-01471251015105Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancersYakup Duzkopru0Abdulkadir Kocanoglu1Mehmet Yigitbay2Ozlem Dogan3Hayriye Sahinli4Dogan Yazilitas5Ankara Etlik City Hospital, Medical Oncology, Ankara, Turkiye; Corresponding author. Ankara Etlik City Hospital, Medical Oncology, Varlik Neighbourhood, Halil Sezai Erkut street, Yenimahalle, Ankara, Turkiye.Ankara Etlik City Hospital, Medical Oncology, Ankara, TurkiyeAkcakale State Hospital, Department of Otorhinolaryngology, Sanliurfa, TurkiyeAnkara Etlik City Hospital, Medical Oncology, Ankara, TurkiyeAnkara Etlik City Hospital, Medical Oncology, Ankara, TurkiyeAnkara Etlik City Hospital, Medical Oncology, Ankara, TurkiyeObjective: This study investigates the prognostic significance of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score and Prognostic Nutritional Index (PNI) in metastatic head and neck cancers. Methods: Retrospective analysis was conducted on data obtained from January 2014 to June 2022 for 68 patients using rigorous statistical methods. HALP and PNI scores, derived from routine laboratory parameters, were categorized into low and high groups using respective median values. Prognostic significance was determined through Kaplan–Meier survival analyses and Cox proportional hazards regression using IBM SPSS Statistics. Results: Of the 68 patients (80.9% male, median age 57), 39 (57.4%) had laryngeal cancer. When stratified by low and high HALP scores, the median overall survival (OS) was 5.9 and 16.4 months, respectively (P < 0.001), while the median progression-free survival (PFS) was 5.7 months and 8.2 months, respectively (P: 0.016). In the low and high PNI score groups, the median OS was 7 and 13.2 months (P < 0.001), with median PFS of 5.6 months and 8.2 months (P: 0.002), respectively. In the multivariate analysis, while the HALP score did not reach statistical significance in terms of PFS, the PNI score and age groups were found to be statistically significant. In terms of OS, higher HALP score and PNI scores were significantly associated with longer OS. Conclusion: In this study, the HALP score and PNI score were found to be a prognostic factor in patients with metastatic head and neck cancer.http://www.sciencedirect.com/science/article/pii/S1015958424007553BiomarkersHALP scoreHead and neck cancerPrognosisPrognostic nutritional index |
| spellingShingle | Yakup Duzkopru Abdulkadir Kocanoglu Mehmet Yigitbay Ozlem Dogan Hayriye Sahinli Dogan Yazilitas Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers Asian Journal of Surgery Biomarkers HALP score Head and neck cancer Prognosis Prognostic nutritional index |
| title | Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers |
| title_full | Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers |
| title_fullStr | Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers |
| title_full_unstemmed | Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers |
| title_short | Analyzing HALP and PNI scores as prognostic factors in metastatic head and neck cancers |
| title_sort | analyzing halp and pni scores as prognostic factors in metastatic head and neck cancers |
| topic | Biomarkers HALP score Head and neck cancer Prognosis Prognostic nutritional index |
| url | http://www.sciencedirect.com/science/article/pii/S1015958424007553 |
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