Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression
Background Various studies have highlighted the increased incidence and symptoms of depression and anxiety in paediatric cancer survivors (PCS). Yet no meta-analysis has focused on post-traumatic stress disorder (PTSD) or post-traumatic stress symptoms (PTSS) in PCS and their family nucleus. Aims T...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-11-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472424008056/type/journal_article |
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| _version_ | 1846171124484800512 |
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| author | Chen Ee Low Sheryl Yen Pin Tan Andre Loh Jingrong Yu Joel Zuo Er Ong Caitlin Yuen Ling Loh Chun En Yau Ainsley Ryan Yan Bin Lee Cyrus Su Hui Ho |
| author_facet | Chen Ee Low Sheryl Yen Pin Tan Andre Loh Jingrong Yu Joel Zuo Er Ong Caitlin Yuen Ling Loh Chun En Yau Ainsley Ryan Yan Bin Lee Cyrus Su Hui Ho |
| author_sort | Chen Ee Low |
| collection | DOAJ |
| description | Background
Various studies have highlighted the increased incidence and symptoms of depression and anxiety in paediatric cancer survivors (PCS). Yet no meta-analysis has focused on post-traumatic stress disorder (PTSD) or post-traumatic stress symptoms (PTSS) in PCS and their family nucleus.
Aims
To evaluate the overall risk of PTSD and severity of PTSS in PCS and their family nucleus. Secondary objectives include identifying potential risk factors of PTSD and high PTSS.
Method
We systematically searched PubMed, Embase and PsycINFO for studies comparing the risk of PTSD and PTSS severity among PCS, their family nucleus and non-cancer controls. PRISMA reporting guidelines were followed. Random effects meta-analyses and meta-regressions were conducted.
Results
From 1089 records, we included 21 studies. PCS have an increased risk of PTSD (risk ratio 2.36, 95% CI 1.37–4.06) and decreased PTSS severity (standardised mean difference −0.29, 95% CI −0.50 to −0.08). Subgroup analyses of other categorical study-level characteristics revealed that female PCS who were older at diagnosis and data collection had a significantly higher risk of PTSD. Meta-regression were insignificant. Family nucleus did not show a significantly increased risk of PTSD (risk ratio 1.13, 95% CI 0.59–5.00) and PTSS severity (standardised mean difference 0.53, 95% CI −0.00 to 1.06). Systematically reviewing studies on the family nucleus found that the majority reported a significantly increased risk of psychological trauma compared with the comparator. Lower education, income and social status were also risk factors.
Conclusions
Timely identification and interventions are imperative for policy makers and healthcare providers to prevent trauma from worsening in this population group.
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| format | Article |
| id | doaj-art-791df11bb4094e189f6bd2cf6f53af0c |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-791df11bb4094e189f6bd2cf6f53af0c2024-11-11T07:03:03ZengCambridge University PressBJPsych Open2056-47242024-11-011010.1192/bjo.2024.805Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regressionChen Ee Low0https://orcid.org/0000-0002-8652-0984Sheryl Yen Pin Tan1Andre Loh2Jingrong Yu3Joel Zuo Er Ong4Caitlin Yuen Ling Loh5Chun En Yau6Ainsley Ryan Yan Bin Lee7Cyrus Su Hui Ho8Yong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and Department of Psychological Medicine, National University Hospital, SingaporeBackground Various studies have highlighted the increased incidence and symptoms of depression and anxiety in paediatric cancer survivors (PCS). Yet no meta-analysis has focused on post-traumatic stress disorder (PTSD) or post-traumatic stress symptoms (PTSS) in PCS and their family nucleus. Aims To evaluate the overall risk of PTSD and severity of PTSS in PCS and their family nucleus. Secondary objectives include identifying potential risk factors of PTSD and high PTSS. Method We systematically searched PubMed, Embase and PsycINFO for studies comparing the risk of PTSD and PTSS severity among PCS, their family nucleus and non-cancer controls. PRISMA reporting guidelines were followed. Random effects meta-analyses and meta-regressions were conducted. Results From 1089 records, we included 21 studies. PCS have an increased risk of PTSD (risk ratio 2.36, 95% CI 1.37–4.06) and decreased PTSS severity (standardised mean difference −0.29, 95% CI −0.50 to −0.08). Subgroup analyses of other categorical study-level characteristics revealed that female PCS who were older at diagnosis and data collection had a significantly higher risk of PTSD. Meta-regression were insignificant. Family nucleus did not show a significantly increased risk of PTSD (risk ratio 1.13, 95% CI 0.59–5.00) and PTSS severity (standardised mean difference 0.53, 95% CI −0.00 to 1.06). Systematically reviewing studies on the family nucleus found that the majority reported a significantly increased risk of psychological trauma compared with the comparator. Lower education, income and social status were also risk factors. Conclusions Timely identification and interventions are imperative for policy makers and healthcare providers to prevent trauma from worsening in this population group. https://www.cambridge.org/core/product/identifier/S2056472424008056/type/journal_articleTrauma and stressor-related disorderssystematic reviewchild and adolescent psychiatrymeta-analysiscarers |
| spellingShingle | Chen Ee Low Sheryl Yen Pin Tan Andre Loh Jingrong Yu Joel Zuo Er Ong Caitlin Yuen Ling Loh Chun En Yau Ainsley Ryan Yan Bin Lee Cyrus Su Hui Ho Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression BJPsych Open Trauma and stressor-related disorders systematic review child and adolescent psychiatry meta-analysis carers |
| title | Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression |
| title_full | Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression |
| title_fullStr | Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression |
| title_full_unstemmed | Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression |
| title_short | Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression |
| title_sort | post traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus systematic review meta analysis and meta regression |
| topic | Trauma and stressor-related disorders systematic review child and adolescent psychiatry meta-analysis carers |
| url | https://www.cambridge.org/core/product/identifier/S2056472424008056/type/journal_article |
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