Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility

Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility

Abstract A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura borylation and Suzuki coupling methodology. Biaryl bridges formed by side chains of the two aromatic amino acid residues are of the meta–meta, meta–p...

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Main Authors: Maria Różanowska, Gabriela Szczupaj, Michał Nowakowski, Priyadharshni Rajagopal, Piotr F. J. Lipiński, Joanna Matalińska, Aleksandra Misicka, Marek Lisowski, Łukasz Jaremko, Mariusz Jaremko
Format: Article
Language:English
Published: Springer 2024-03-01
Series:Amino Acids
Subjects:
Cyclization
Biaryl bridges in peptides
Miyaura–Suzuki reaction
NMR
CD
Molecular docking
Online Access:https://doi.org/10.1007/s00726-023-03371-5
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https://doi.org/10.1007/s00726-023-03371-5

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