Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets
Abstract The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on a global scale. A substantial body of evidence indicates that there is a complex relationship between obesity and OP, with a correlation between the occurrence of OP and obesity. In recent year...
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BMC
2025-01-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-024-02025-7 |
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| author | Yikuan Du Yuying Huo Yujia Yang Peiqi Lin Wuzheng Liu Ziqin Wang Wenqi Zeng Jiahui Li Zhonghan Liang Chenyue Yuan Jinfeng Zhu Ziyi Luo Yi Liu Chunling Ma Chun Yang |
| author_facet | Yikuan Du Yuying Huo Yujia Yang Peiqi Lin Wuzheng Liu Ziqin Wang Wenqi Zeng Jiahui Li Zhonghan Liang Chenyue Yuan Jinfeng Zhu Ziyi Luo Yi Liu Chunling Ma Chun Yang |
| author_sort | Yikuan Du |
| collection | DOAJ |
| description | Abstract The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on a global scale. A substantial body of evidence indicates that there is a complex relationship between obesity and OP, with a correlation between the occurrence of OP and obesity. In recent years, sirtuins have emerged as a prominent area of interest in the fields of aging and endocrine metabolism. Among the various research avenues exploring the potential of sirtuins, the effects of these proteins on obesity and OP have garnered significant attention from numerous researchers. Sirtuins regulate energy balance and lipid balance, which in turn inhibit the process of adipogenesis. Additionally, sirtuins regulate the balance between osteogenic and osteoblastic activity, which protects against the development of OP. However, no study has yet provided a comprehensive discussion of the relationship between the three: sirtuins, obesity, and OP. This paper will therefore describe the relationship between sirtuins and obesity, the relationship between sirtuins and OP, and a discussion focusing on the possibility of treating OP caused by obesity by targeting sirtuins. This will be based on the common influences on the occurrence of obesity and OP (such as mesenchymal stem cells, gut microbiota, and insulin). Finally, the potential of SIRT1, an important member of sirtuins, in polyphenolic natural products for the treatment of obesity and OP will be presented. This will contribute to a better understanding of the interactions between sirtuins and obesity and bone, which will facilitate the development of new therapeutic strategies for obesity and OP in the future. |
| format | Article |
| id | doaj-art-7911bda9fc91413eae27303163694ada |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-7911bda9fc91413eae27303163694ada2025-01-12T12:33:01ZengBMCCell Communication and Signaling1478-811X2025-01-0123113710.1186/s12964-024-02025-7Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targetsYikuan Du0Yuying Huo1Yujia Yang2Peiqi Lin3Wuzheng Liu4Ziqin Wang5Wenqi Zeng6Jiahui Li7Zhonghan Liang8Chenyue Yuan9Jinfeng Zhu10Ziyi Luo11Yi Liu12Chunling Ma13Chun Yang14Central Laboratory, The Tenth Affiliated Hospital of Southern Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityThe First Dongguan Affiliated Hospital, Guangdong Medical UniversityThe First Dongguan Affiliated Hospital, Guangdong Medical UniversityDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical UniversityAbstract The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on a global scale. A substantial body of evidence indicates that there is a complex relationship between obesity and OP, with a correlation between the occurrence of OP and obesity. In recent years, sirtuins have emerged as a prominent area of interest in the fields of aging and endocrine metabolism. Among the various research avenues exploring the potential of sirtuins, the effects of these proteins on obesity and OP have garnered significant attention from numerous researchers. Sirtuins regulate energy balance and lipid balance, which in turn inhibit the process of adipogenesis. Additionally, sirtuins regulate the balance between osteogenic and osteoblastic activity, which protects against the development of OP. However, no study has yet provided a comprehensive discussion of the relationship between the three: sirtuins, obesity, and OP. This paper will therefore describe the relationship between sirtuins and obesity, the relationship between sirtuins and OP, and a discussion focusing on the possibility of treating OP caused by obesity by targeting sirtuins. This will be based on the common influences on the occurrence of obesity and OP (such as mesenchymal stem cells, gut microbiota, and insulin). Finally, the potential of SIRT1, an important member of sirtuins, in polyphenolic natural products for the treatment of obesity and OP will be presented. This will contribute to a better understanding of the interactions between sirtuins and obesity and bone, which will facilitate the development of new therapeutic strategies for obesity and OP in the future.https://doi.org/10.1186/s12964-024-02025-7SirtuinsObesityOsteoporosisMesenchymal stem cellsGut microbiotaInsulin |
| spellingShingle | Yikuan Du Yuying Huo Yujia Yang Peiqi Lin Wuzheng Liu Ziqin Wang Wenqi Zeng Jiahui Li Zhonghan Liang Chenyue Yuan Jinfeng Zhu Ziyi Luo Yi Liu Chunling Ma Chun Yang Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets Cell Communication and Signaling Sirtuins Obesity Osteoporosis Mesenchymal stem cells Gut microbiota Insulin |
| title | Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets |
| title_full | Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets |
| title_fullStr | Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets |
| title_full_unstemmed | Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets |
| title_short | Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets |
| title_sort | role of sirtuins in obesity and osteoporosis molecular mechanisms and therapeutic targets |
| topic | Sirtuins Obesity Osteoporosis Mesenchymal stem cells Gut microbiota Insulin |
| url | https://doi.org/10.1186/s12964-024-02025-7 |
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