Copper-mediated radiochemistry: historical impact, current trends, and future possibilities
Abstract Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials, and it has been adapted for radionuclides beyond fl...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Imaging |
| Online Access: | https://doi.org/10.1038/s44303-025-00087-x |
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| _version_ | 1849334544733306880 |
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| author | Gregory D. Bowden Marius Müller Matthias M. Herth Melanie S. Sanford Peter J. H. Scott |
| author_facet | Gregory D. Bowden Marius Müller Matthias M. Herth Melanie S. Sanford Peter J. H. Scott |
| author_sort | Gregory D. Bowden |
| collection | DOAJ |
| description | Abstract Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials, and it has been adapted for radionuclides beyond fluorine-18, enabling theranostic applications. The methodology is also beginning to benefit from AI-assisted radiochemistry development. This perspective discusses the history, state-of-the-art, and potential future impact of copper-mediated radiochemistry on radiopharmaceutical development. |
| format | Article |
| id | doaj-art-7907d1e9109a4f51a8e09ac43a651d4f |
| institution | Kabale University |
| issn | 2948-197X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Imaging |
| spelling | doaj-art-7907d1e9109a4f51a8e09ac43a651d4f2025-08-20T03:45:32ZengNature Portfolionpj Imaging2948-197X2025-06-013111210.1038/s44303-025-00087-xCopper-mediated radiochemistry: historical impact, current trends, and future possibilitiesGregory D. Bowden0Marius Müller1Matthias M. Herth2Melanie S. Sanford3Peter J. H. Scott4Department of Radiology, University of Michigan, 1301 CatherineDepartment of Radiology, University of Michigan, 1301 CatherineDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2Department of Chemistry, University of Michigan, 930 N University AvenueDepartment of Radiology, University of Michigan, 1301 CatherineAbstract Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials, and it has been adapted for radionuclides beyond fluorine-18, enabling theranostic applications. The methodology is also beginning to benefit from AI-assisted radiochemistry development. This perspective discusses the history, state-of-the-art, and potential future impact of copper-mediated radiochemistry on radiopharmaceutical development.https://doi.org/10.1038/s44303-025-00087-x |
| spellingShingle | Gregory D. Bowden Marius Müller Matthias M. Herth Melanie S. Sanford Peter J. H. Scott Copper-mediated radiochemistry: historical impact, current trends, and future possibilities npj Imaging |
| title | Copper-mediated radiochemistry: historical impact, current trends, and future possibilities |
| title_full | Copper-mediated radiochemistry: historical impact, current trends, and future possibilities |
| title_fullStr | Copper-mediated radiochemistry: historical impact, current trends, and future possibilities |
| title_full_unstemmed | Copper-mediated radiochemistry: historical impact, current trends, and future possibilities |
| title_short | Copper-mediated radiochemistry: historical impact, current trends, and future possibilities |
| title_sort | copper mediated radiochemistry historical impact current trends and future possibilities |
| url | https://doi.org/10.1038/s44303-025-00087-x |
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