Variation in human gut microbiota impacts tamoxifen pharmacokinetics

Variation in human gut microbiota impacts tamoxifen pharmacokinetics

ABSTRACT Tamoxifen is the most prescribed drug used to prevent breast cancer recurrence, but patients show variable responses to tamoxifen. Such differential inter-individual response has a significant socioeconomic impact as one in eight women will develop breast cancer and nearly half a million pe...

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Main Authors: Yasmine Alam, Sheron Hakopian, Lizett Ortiz de Ora, Ian Tamburini, Julio Avelar-Barragan, Sunhee Jung, Zane Long, Alina Chao, Katrine Whiteson, Cholsoon Jang, Elizabeth Bess
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
Subjects:
human gut microbiome
tamoxifen
breast cancer
Online Access:https://journals.asm.org/doi/10.1128/mbio.01679-24
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