Evidence of a novel α-synuclein strain isolated from a Parkinson’s disease with dementia patient sample

Evidence of a novel α-synuclein strain isolated from a Parkinson’s disease with dementia patient sample

Abstract Multiple system atrophy (MSA) and the Lewy body diseases (LBDs) are caused by α-synuclein misfolding into distinct conformations, or strains, with unique biological properties. MSA patient samples readily transmit disease following intracranial (i.c.) inoculation into humanized mice, wherea...

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Bibliographic Details
Main Authors: Sara A. M. Holec, Jisoo Lee, Chase R. Khedmatgozar, Marcelina J. Wojewska, Abby Oehler, Glenda M. Halliday, Steve M. Gentleman, Amanda L. Woerman
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Acta Neuropathologica Communications
Subjects:
Lewy body diseases
Neurodegenerative disease
Strain interactions
Synucleinopathies
Online Access:https://doi.org/10.1186/s40478-025-02093-x
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