Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China
Background. The strength of associations between total testosterone (TT) and metabolic parameters may vary in different nature of population structure; however, no study has ever given this information in Chinese population, especially those without metabolic syndrome (MS). We aimed to analyze the a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/4547658 |
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| author | Jing Cheng Bing Han Qin Li Fangzhen Xia Hualing Zhai Ningjian Wang Michael Jensen Yingli Lu |
| author_facet | Jing Cheng Bing Han Qin Li Fangzhen Xia Hualing Zhai Ningjian Wang Michael Jensen Yingli Lu |
| author_sort | Jing Cheng |
| collection | DOAJ |
| description | Background. The strength of associations between total testosterone (TT) and metabolic parameters may vary in different nature of population structure; however, no study has ever given this information in Chinese population, especially those without metabolic syndrome (MS). We aimed to analyze the association magnitudes between TT and multiple metabolic parameters in general Chinese men. Methods. 4309 men were recruited from SPECT-China study in 2014-2015, which was performed in 22 sites in East China. TT, weight status, and various metabolic parameters were measured. Linear and logistic regressions were used to analyze the associations. Results. Men in lower TT quartiles had worse metabolic parameters including body mass index, triglycerides, HbA1c, and HOMA-IR (all P for trend < 0.001). Body mass index (B −0.32, 95%CI −0.35 to −0.29) and obesity (OR 0.40, 95%CI 0.35–0.45) had the largest association magnitude per one SD increment in TT, while blood pressure and hypertension (OR 0.90, 95%CI 0.84–0.98) had the smallest. These associations also persisted in individuals without metabolic syndrome. Conclusions. Obesity indices had closer relationships with TT than most other metabolic measures with blood pressure the least close. These associations remained robust after adjustment for adiposity and in subjects without metabolic syndrome. |
| format | Article |
| id | doaj-art-78f273f04d174c2da2eea6a00f360e4c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-78f273f04d174c2da2eea6a00f360e4c2025-02-03T05:53:01ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/45476584547658Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-ChinaJing Cheng0Bing Han1Qin Li2Fangzhen Xia3Hualing Zhai4Ningjian Wang5Michael Jensen6Yingli Lu7Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaEndocrine Research Unit, Mayo Clinic, Rochester, MN, USAInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackground. The strength of associations between total testosterone (TT) and metabolic parameters may vary in different nature of population structure; however, no study has ever given this information in Chinese population, especially those without metabolic syndrome (MS). We aimed to analyze the association magnitudes between TT and multiple metabolic parameters in general Chinese men. Methods. 4309 men were recruited from SPECT-China study in 2014-2015, which was performed in 22 sites in East China. TT, weight status, and various metabolic parameters were measured. Linear and logistic regressions were used to analyze the associations. Results. Men in lower TT quartiles had worse metabolic parameters including body mass index, triglycerides, HbA1c, and HOMA-IR (all P for trend < 0.001). Body mass index (B −0.32, 95%CI −0.35 to −0.29) and obesity (OR 0.40, 95%CI 0.35–0.45) had the largest association magnitude per one SD increment in TT, while blood pressure and hypertension (OR 0.90, 95%CI 0.84–0.98) had the smallest. These associations also persisted in individuals without metabolic syndrome. Conclusions. Obesity indices had closer relationships with TT than most other metabolic measures with blood pressure the least close. These associations remained robust after adjustment for adiposity and in subjects without metabolic syndrome.http://dx.doi.org/10.1155/2017/4547658 |
| spellingShingle | Jing Cheng Bing Han Qin Li Fangzhen Xia Hualing Zhai Ningjian Wang Michael Jensen Yingli Lu Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China International Journal of Endocrinology |
| title | Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China |
| title_full | Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China |
| title_fullStr | Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China |
| title_full_unstemmed | Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China |
| title_short | Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China |
| title_sort | testosterone relationships with metabolic disorders in men an observational study from spect china |
| url | http://dx.doi.org/10.1155/2017/4547658 |
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