Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review
Abstract Background Breast cancer (BC) continues to be a significant global health issue, with a rising number of cases requiring ongoing research and innovation in treatment strategies. Curcumin (CUR), a natural compound derived from Curcuma longa, and similar compounds have shown potential in targ...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Animal Models and Experimental Medicine |
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| Online Access: | https://doi.org/10.1002/ame2.12491 |
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| author | Maryam Golmohammadi Mohammad Yassin Zamanian Ahmed Muzahem Al‐Ani Thaer L. Jabbar Ali Kamil Kareem Zeinab Hashem Aghaei Hossein Tahernia Ahmed Hjazi Saad Abdul‐ridh Jissir Elham Hakimizadeh |
| author_facet | Maryam Golmohammadi Mohammad Yassin Zamanian Ahmed Muzahem Al‐Ani Thaer L. Jabbar Ali Kamil Kareem Zeinab Hashem Aghaei Hossein Tahernia Ahmed Hjazi Saad Abdul‐ridh Jissir Elham Hakimizadeh |
| author_sort | Maryam Golmohammadi |
| collection | DOAJ |
| description | Abstract Background Breast cancer (BC) continues to be a significant global health issue, with a rising number of cases requiring ongoing research and innovation in treatment strategies. Curcumin (CUR), a natural compound derived from Curcuma longa, and similar compounds have shown potential in targeting the STAT3 signaling pathway, which plays a crucial role in BC progression. Aims The aim of this study was to investigate the effects of curcumin and its analogues on BC based on cellular and molecular mechanisms. Materials & Methods The literature search conducted for this study involved utilizing the Scopus, ScienceDirect, PubMed, and Google Scholar databases in order to identify pertinent articles. Results This narrative review explores the potential of CUR and similar compounds in inhibiting STAT3 activation, thereby suppressing the proliferation of cancer cells, inducing apoptosis, and inhibiting metastasis. The review demonstrates that CUR directly inhibits the phosphorylation of STAT3, preventing its movement into the nucleus and its ability to bind to DNA, thereby hindering the survival and proliferation of cancer cells. CUR also enhances the effectiveness of other therapeutic agents and modulates the tumor microenvironment by affecting tumor‐associated macrophages (TAMs). CUR analogues, such as hydrazinocurcumin (HC), FLLL11, FLLL12, and GO‐Y030, show improved bioavailability and potency in inhibiting STAT3, resulting in reduced cell proliferation and increased apoptosis. Conclusion CUR and its analogues hold promise as effective adjuvant treatments for BC by targeting the STAT3 signaling pathway. These compounds provide new insights into the mechanisms of action of CUR and its potential to enhance the effectiveness of BC therapies. |
| format | Article |
| id | doaj-art-78eb667bbef84143ab5dea16cc7bff8f |
| institution | Kabale University |
| issn | 2576-2095 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj-art-78eb667bbef84143ab5dea16cc7bff8f2024-12-28T05:24:15ZengWileyAnimal Models and Experimental Medicine2576-20952024-12-017685386710.1002/ame2.12491Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative reviewMaryam Golmohammadi0Mohammad Yassin Zamanian1Ahmed Muzahem Al‐Ani2Thaer L. Jabbar3Ali Kamil Kareem4Zeinab Hashem Aghaei5Hossein Tahernia6Ahmed Hjazi7Saad Abdul‐ridh Jissir8Elham Hakimizadeh9School of Medicine Shahid Beheshti University of Medical Sciences Tehran IranDepartment of Physiology, School of Medicine Hamadan University of Medical Sciences Hamadan IranDepartment of Medical Laboratories Technology AL‐Nisour University College Baghdad IraqCollege of pharmacy Al‐ Ayen University Nasiriyah IraqBiomedical Engineering Department Al‐Mustaqbal University College Hillah IraqPreventative Gynecology Research Center Shahid Beheshti University of Medical Sciences Tehran IranMolecular Medicine Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences Rafsanjan IranDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Al‐Kharj Saudi ArabiaCollege of Nursing Al‐Bayan University Baghdad IraqPhysiology‐Pharmacology Research Center, Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences Rafsanjan IranAbstract Background Breast cancer (BC) continues to be a significant global health issue, with a rising number of cases requiring ongoing research and innovation in treatment strategies. Curcumin (CUR), a natural compound derived from Curcuma longa, and similar compounds have shown potential in targeting the STAT3 signaling pathway, which plays a crucial role in BC progression. Aims The aim of this study was to investigate the effects of curcumin and its analogues on BC based on cellular and molecular mechanisms. Materials & Methods The literature search conducted for this study involved utilizing the Scopus, ScienceDirect, PubMed, and Google Scholar databases in order to identify pertinent articles. Results This narrative review explores the potential of CUR and similar compounds in inhibiting STAT3 activation, thereby suppressing the proliferation of cancer cells, inducing apoptosis, and inhibiting metastasis. The review demonstrates that CUR directly inhibits the phosphorylation of STAT3, preventing its movement into the nucleus and its ability to bind to DNA, thereby hindering the survival and proliferation of cancer cells. CUR also enhances the effectiveness of other therapeutic agents and modulates the tumor microenvironment by affecting tumor‐associated macrophages (TAMs). CUR analogues, such as hydrazinocurcumin (HC), FLLL11, FLLL12, and GO‐Y030, show improved bioavailability and potency in inhibiting STAT3, resulting in reduced cell proliferation and increased apoptosis. Conclusion CUR and its analogues hold promise as effective adjuvant treatments for BC by targeting the STAT3 signaling pathway. These compounds provide new insights into the mechanisms of action of CUR and its potential to enhance the effectiveness of BC therapies.https://doi.org/10.1002/ame2.12491apoptosiscell proliferationcurcumincurcumin analoguesSTAT3 |
| spellingShingle | Maryam Golmohammadi Mohammad Yassin Zamanian Ahmed Muzahem Al‐Ani Thaer L. Jabbar Ali Kamil Kareem Zeinab Hashem Aghaei Hossein Tahernia Ahmed Hjazi Saad Abdul‐ridh Jissir Elham Hakimizadeh Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review Animal Models and Experimental Medicine apoptosis cell proliferation curcumin curcumin analogues STAT3 |
| title | Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review |
| title_full | Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review |
| title_fullStr | Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review |
| title_full_unstemmed | Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review |
| title_short | Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review |
| title_sort | targeting stat3 signaling pathway by curcumin and its analogues for breast cancer a narrative review |
| topic | apoptosis cell proliferation curcumin curcumin analogues STAT3 |
| url | https://doi.org/10.1002/ame2.12491 |
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