Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography
Abstract The eye and the heart are two closely interlinked organs, and many diseases affecting the cardiovascular system manifest in the eye. To contribute to the understanding of blood flow propagation towards the retina, we developed a method to acquire electrocardiogram (ECG) coupled time-resolve...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84417-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559670701948928 |
|---|---|
| author | Philippe Valmaggia Julia Wolleb Florentin Bieder Hendrik P. N. Scholl Philippe C. Cattin Peter M. Maloca |
| author_facet | Philippe Valmaggia Julia Wolleb Florentin Bieder Hendrik P. N. Scholl Philippe C. Cattin Peter M. Maloca |
| author_sort | Philippe Valmaggia |
| collection | DOAJ |
| description | Abstract The eye and the heart are two closely interlinked organs, and many diseases affecting the cardiovascular system manifest in the eye. To contribute to the understanding of blood flow propagation towards the retina, we developed a method to acquire electrocardiogram (ECG) coupled time-resolved dynamic optical coherence tomography (OCT) images. This method allows for continuous synchronised monitoring of the cardiac cycle and retinal blood flow dynamics. The dynamic OCT measurements were used to calculate time-resolved blood flow profiles using fringe washout analysis. The relative fringe washout was computed to generate the flow velocity profiles within arterioles at the optic nerve head rim. We found that the blood column between the heart and the retina propagates within one cardiac cycle, denoting the arrival time as the heart-retina time (HRT). In a group of healthy subjects, the HRT was 144 ± 19 ms (mean ± SD). The HRT could provide a novel potential biomarker for cardiovascular health in direct relation to retinal perfusion. |
| format | Article |
| id | doaj-art-78af51e4a3274f4b93edd84cf635af89 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-78af51e4a3274f4b93edd84cf635af892025-01-05T12:18:17ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-024-84417-wHeart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomographyPhilippe Valmaggia0Julia Wolleb1Florentin Bieder2Hendrik P. N. Scholl3Philippe C. Cattin4Peter M. Maloca5Department of Biomedical Engineering, University of BaselDepartment of Biomedical Engineering, University of BaselDepartment of Biomedical Engineering, University of BaselDepartment of Ophthalmology, University Hospital BaselDepartment of Biomedical Engineering, University of BaselInstitute of Molecular and Clinical Ophthalmology Basel (IOB)Abstract The eye and the heart are two closely interlinked organs, and many diseases affecting the cardiovascular system manifest in the eye. To contribute to the understanding of blood flow propagation towards the retina, we developed a method to acquire electrocardiogram (ECG) coupled time-resolved dynamic optical coherence tomography (OCT) images. This method allows for continuous synchronised monitoring of the cardiac cycle and retinal blood flow dynamics. The dynamic OCT measurements were used to calculate time-resolved blood flow profiles using fringe washout analysis. The relative fringe washout was computed to generate the flow velocity profiles within arterioles at the optic nerve head rim. We found that the blood column between the heart and the retina propagates within one cardiac cycle, denoting the arrival time as the heart-retina time (HRT). In a group of healthy subjects, the HRT was 144 ± 19 ms (mean ± SD). The HRT could provide a novel potential biomarker for cardiovascular health in direct relation to retinal perfusion.https://doi.org/10.1038/s41598-024-84417-wDynamic optical coherence tomographyRetinal blood flowElectrocardiogramCardiac cycleHeart-retina time |
| spellingShingle | Philippe Valmaggia Julia Wolleb Florentin Bieder Hendrik P. N. Scholl Philippe C. Cattin Peter M. Maloca Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography Scientific Reports Dynamic optical coherence tomography Retinal blood flow Electrocardiogram Cardiac cycle Heart-retina time |
| title | Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography |
| title_full | Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography |
| title_fullStr | Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography |
| title_full_unstemmed | Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography |
| title_short | Heart-retina time analysis using electrocardiogram-coupled time-resolved dynamic optical coherence tomography |
| title_sort | heart retina time analysis using electrocardiogram coupled time resolved dynamic optical coherence tomography |
| topic | Dynamic optical coherence tomography Retinal blood flow Electrocardiogram Cardiac cycle Heart-retina time |
| url | https://doi.org/10.1038/s41598-024-84417-w |
| work_keys_str_mv | AT philippevalmaggia heartretinatimeanalysisusingelectrocardiogramcoupledtimeresolveddynamicopticalcoherencetomography AT juliawolleb heartretinatimeanalysisusingelectrocardiogramcoupledtimeresolveddynamicopticalcoherencetomography AT florentinbieder heartretinatimeanalysisusingelectrocardiogramcoupledtimeresolveddynamicopticalcoherencetomography AT hendrikpnscholl heartretinatimeanalysisusingelectrocardiogramcoupledtimeresolveddynamicopticalcoherencetomography AT philippeccattin heartretinatimeanalysisusingelectrocardiogramcoupledtimeresolveddynamicopticalcoherencetomography AT petermmaloca heartretinatimeanalysisusingelectrocardiogramcoupledtimeresolveddynamicopticalcoherencetomography |