A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis
Background: Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis (PLCA). Many therapeutic modalities, including topical and systemic medications, phototherapy, photochemotherapy, dermabrasion, and lasers have been suggested for PLCA with variable efficacy....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
|
| Series: | Pigment International |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/pigmentinternational.pigmentinternational_7_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558846000070656 |
|---|---|
| author | Roshany Sakthibalan Brinda G David Roshni Menon |
| author_facet | Roshany Sakthibalan Brinda G David Roshni Menon |
| author_sort | Roshany Sakthibalan |
| collection | DOAJ |
| description | Background: Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis (PLCA). Many therapeutic modalities, including topical and systemic medications, phototherapy, photochemotherapy, dermabrasion, and lasers have been suggested for PLCA with variable efficacy. Over the past decade, several studies have reported successful treatment of PLCA with different types of lasers. Aim: To evaluate the efficacy and safety profile of fractional carbon dioxide laser (FrCO2) in primary cutaneous MA. Methods: Using the consecutive sampling technique, 30 clinically confirmed cases of MA aged 18 years and above attending the dermatology out-patient department were recruited for a prospective, single group, interventional study. Each patient received three sessions with 4 weeks interval and then subsequently monitored for 20 weeks. The degree of pigmentation, rippling, itching, overall progress, and patient satisfaction were graded and compared for each patient. SPSS software version 23.0 was used for data analysis. Results: There was a statistically significant (P < 0.001) improvement in the mean percentage of the degree of pigmentation, itching (P < 0.001), and rippling scores (P = 0.03). Marked patient satisfaction was noted at 20 weeks. The excellent safety profile was noted. Conclusion: Our study has shown a positive response to treating MA with FrCO2 laser. Patients were highly satisfied, as there was a significant reduction in itching, pigmentation, and area of the skin lesion with no significant side effects. Our study points towards better efficacy of FrCO2 laser in MA with a good safety profile and better patient satisfaction. |
| format | Article |
| id | doaj-art-78aad1b32c57436ca33c20353580420f |
| institution | Kabale University |
| issn | 2349-5847 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Pigment International |
| spelling | doaj-art-78aad1b32c57436ca33c20353580420f2025-01-06T05:04:02ZengWolters Kluwer Medknow PublicationsPigment International2349-58472024-01-01111273210.4103/pigmentinternational.pigmentinternational_7_23A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosisRoshany SakthibalanBrinda G DavidRoshni MenonBackground: Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis (PLCA). Many therapeutic modalities, including topical and systemic medications, phototherapy, photochemotherapy, dermabrasion, and lasers have been suggested for PLCA with variable efficacy. Over the past decade, several studies have reported successful treatment of PLCA with different types of lasers. Aim: To evaluate the efficacy and safety profile of fractional carbon dioxide laser (FrCO2) in primary cutaneous MA. Methods: Using the consecutive sampling technique, 30 clinically confirmed cases of MA aged 18 years and above attending the dermatology out-patient department were recruited for a prospective, single group, interventional study. Each patient received three sessions with 4 weeks interval and then subsequently monitored for 20 weeks. The degree of pigmentation, rippling, itching, overall progress, and patient satisfaction were graded and compared for each patient. SPSS software version 23.0 was used for data analysis. Results: There was a statistically significant (P < 0.001) improvement in the mean percentage of the degree of pigmentation, itching (P < 0.001), and rippling scores (P = 0.03). Marked patient satisfaction was noted at 20 weeks. The excellent safety profile was noted. Conclusion: Our study has shown a positive response to treating MA with FrCO2 laser. Patients were highly satisfied, as there was a significant reduction in itching, pigmentation, and area of the skin lesion with no significant side effects. Our study points towards better efficacy of FrCO2 laser in MA with a good safety profile and better patient satisfaction.https://journals.lww.com/10.4103/pigmentinternational.pigmentinternational_7_23fractional carbon dioxide lasermacular amyloidosisprimary localized cutaneous amyloidosis |
| spellingShingle | Roshany Sakthibalan Brinda G David Roshni Menon A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis Pigment International fractional carbon dioxide laser macular amyloidosis primary localized cutaneous amyloidosis |
| title | A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis |
| title_full | A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis |
| title_fullStr | A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis |
| title_full_unstemmed | A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis |
| title_short | A prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis |
| title_sort | prospective interventional study on efficacy of fractional carbon dioxide laser in primary cutaneous macular amyloidosis |
| topic | fractional carbon dioxide laser macular amyloidosis primary localized cutaneous amyloidosis |
| url | https://journals.lww.com/10.4103/pigmentinternational.pigmentinternational_7_23 |
| work_keys_str_mv | AT roshanysakthibalan aprospectiveinterventionalstudyonefficacyoffractionalcarbondioxidelaserinprimarycutaneousmacularamyloidosis AT brindagdavid aprospectiveinterventionalstudyonefficacyoffractionalcarbondioxidelaserinprimarycutaneousmacularamyloidosis AT roshnimenon aprospectiveinterventionalstudyonefficacyoffractionalcarbondioxidelaserinprimarycutaneousmacularamyloidosis AT roshanysakthibalan prospectiveinterventionalstudyonefficacyoffractionalcarbondioxidelaserinprimarycutaneousmacularamyloidosis AT brindagdavid prospectiveinterventionalstudyonefficacyoffractionalcarbondioxidelaserinprimarycutaneousmacularamyloidosis AT roshnimenon prospectiveinterventionalstudyonefficacyoffractionalcarbondioxidelaserinprimarycutaneousmacularamyloidosis |