Self-assembled transdermal nanogels control scar formation by inhibiting fibroblast proliferation and fibrosis with glycolysis regulation via the PI3K/Akt/mTOR pathway

Self-assembled transdermal nanogels control scar formation by inhibiting fibroblast proliferation and fibrosis with glycolysis regulation via the PI3K/Akt/mTOR pathway

Abstract Hypertrophic scar (HS) is one of the most common challenges in the field of plastic and reconstructive surgery. HS formation is associated with the abnormal activation of fibroblasts. These fibroblasts exhibit excessive proliferative and fibrotic behavior, which can be induced by glycolysis...

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Bibliographic Details
Main Authors: Xinxian Meng, Zhixi Yu, Shiqi Wu, Wanyu Xu, Yuzhen Tang, Zixuan Chen, Yixin Zhang, Yunsheng Chen, Zheng Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Hypertrophic scar
Glycolysis regulation
Transdermal delivery
Fibroblast
Nanogels
Online Access:https://doi.org/10.1186/s12951-025-03562-0
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