High Fructose Consumption and Metabolic Syndrome from Gout Perspective
Uric acid is formed as a consequence of the catabolism of purine nucleotides. The removal of uric acid from the body is mainly carried out by the kidneys via urine and, to a lesser extent, by the intestinal tract via feces. Excretion and reabsorption of uric acid from the intestinal tract, and espec...
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2024-08-01
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| Series: | Cerrahpaşa Medical Journal |
| Online Access: | https://cerrahpasamedj.org/en/high-fructose-consumption-and-metabolic-syndrome-from-gout-perspective-131264 |
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| author | Ümmühan Fulden Aydın Erkan Kozanoğlu Abdullah Tuli |
| author_facet | Ümmühan Fulden Aydın Erkan Kozanoğlu Abdullah Tuli |
| author_sort | Ümmühan Fulden Aydın |
| collection | DOAJ |
| description | Uric acid is formed as a consequence of the catabolism of purine nucleotides. The removal of uric acid from the body is mainly carried out by the kidneys via urine and, to a lesser extent, by the intestinal tract via feces. Excretion and reabsorption of uric acid from the intestinal tract, and especially from the kidneys, are carried out by special transporters. Genetic variations in these carriers have been related to increased or decreased serum uric acid levels. Uric acid synthesis increases for various reasons that increase the destruction of purine nucleotides, causing serum uric acid levels to rise. Although hyperuricemia, with a mean serum uric acid level above 6.8 mg/dL, does not always cause gout, if hyperuricemia is not kept under control, it can result in gout; an inflammatory disease characterized by the crystallization of monosodium urate. As well as non-modifiable factors such as age and ethnicity; diet, which is one of the modifiable factors, can promote gout or recurrence of gout flare-ups. Excessive consumption of products with high fructose content can cause hyperuricemia and gout. In addition, the increase in uric acid resulting from excessive consumption of fructose, and overall and sustained high serum uric acid levels have been shown to cause various disorders that will give rise to metabolic syndrome. In this review, the interwoven relationships between hyperuricemia—an increase in serum uric acid levels—and the resulting gout, as well as metabolic syndrome, and the role excessive fructose consumption plays in these, have been investigated. |
| format | Article |
| id | doaj-art-788525e4f22f4c1b9f8682fdac792823 |
| institution | Kabale University |
| issn | 2687-1904 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | AVES |
| record_format | Article |
| series | Cerrahpaşa Medical Journal |
| spelling | doaj-art-788525e4f22f4c1b9f8682fdac7928232024-12-05T16:30:41ZengAVESCerrahpaşa Medical Journal2687-19042024-08-0148219119610.5152/cjm.2024.24001High Fructose Consumption and Metabolic Syndrome from Gout PerspectiveÜmmühan Fulden Aydın0Erkan Kozanoğlu1Abdullah Tuli2Department of Medical Biochemistry, Çukurova University, Faculty of Medicine, Adana, TürkiyeDepartment of Physical Medicine and Rehabilitation, Çukurova University, Faculty of Medicine, Adana, TürkiyeDepartment of Medical Biochemistry, Çukurova University, Faculty of Medicine, Adana, TürkiyeUric acid is formed as a consequence of the catabolism of purine nucleotides. The removal of uric acid from the body is mainly carried out by the kidneys via urine and, to a lesser extent, by the intestinal tract via feces. Excretion and reabsorption of uric acid from the intestinal tract, and especially from the kidneys, are carried out by special transporters. Genetic variations in these carriers have been related to increased or decreased serum uric acid levels. Uric acid synthesis increases for various reasons that increase the destruction of purine nucleotides, causing serum uric acid levels to rise. Although hyperuricemia, with a mean serum uric acid level above 6.8 mg/dL, does not always cause gout, if hyperuricemia is not kept under control, it can result in gout; an inflammatory disease characterized by the crystallization of monosodium urate. As well as non-modifiable factors such as age and ethnicity; diet, which is one of the modifiable factors, can promote gout or recurrence of gout flare-ups. Excessive consumption of products with high fructose content can cause hyperuricemia and gout. In addition, the increase in uric acid resulting from excessive consumption of fructose, and overall and sustained high serum uric acid levels have been shown to cause various disorders that will give rise to metabolic syndrome. In this review, the interwoven relationships between hyperuricemia—an increase in serum uric acid levels—and the resulting gout, as well as metabolic syndrome, and the role excessive fructose consumption plays in these, have been investigated.https://cerrahpasamedj.org/en/high-fructose-consumption-and-metabolic-syndrome-from-gout-perspective-131264 |
| spellingShingle | Ümmühan Fulden Aydın Erkan Kozanoğlu Abdullah Tuli High Fructose Consumption and Metabolic Syndrome from Gout Perspective Cerrahpaşa Medical Journal |
| title | High Fructose Consumption and Metabolic Syndrome from Gout Perspective |
| title_full | High Fructose Consumption and Metabolic Syndrome from Gout Perspective |
| title_fullStr | High Fructose Consumption and Metabolic Syndrome from Gout Perspective |
| title_full_unstemmed | High Fructose Consumption and Metabolic Syndrome from Gout Perspective |
| title_short | High Fructose Consumption and Metabolic Syndrome from Gout Perspective |
| title_sort | high fructose consumption and metabolic syndrome from gout perspective |
| url | https://cerrahpasamedj.org/en/high-fructose-consumption-and-metabolic-syndrome-from-gout-perspective-131264 |
| work_keys_str_mv | AT ummuhanfuldenaydın highfructoseconsumptionandmetabolicsyndromefromgoutperspective AT erkankozanoglu highfructoseconsumptionandmetabolicsyndromefromgoutperspective AT abdullahtuli highfructoseconsumptionandmetabolicsyndromefromgoutperspective |