Neuroinflammation and major depressive disorder: astrocytes at the crossroads
Major depressive disorder is a complex and multifactorial condition, increasingly linked to neuroinflammation and astrocytic dysfunction. Astrocytes, along with other glial cells, beyond their classic functions in maintaining brain homeostasis, play a crucial role in regulating neuroinflammation and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1504555/full |
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| author | Melissa Puentes-Orozco Melissa Puentes-Orozco Sonia L. Albarracin María Marcela Velásquez |
| author_facet | Melissa Puentes-Orozco Melissa Puentes-Orozco Sonia L. Albarracin María Marcela Velásquez |
| author_sort | Melissa Puentes-Orozco |
| collection | DOAJ |
| description | Major depressive disorder is a complex and multifactorial condition, increasingly linked to neuroinflammation and astrocytic dysfunction. Astrocytes, along with other glial cells, beyond their classic functions in maintaining brain homeostasis, play a crucial role in regulating neuroinflammation and neuroplasticity, key processes in the pathophysiology of depression. This mini-review explores the involvement of astrocytes in depression emphasizing their mediation in neuroinflammation processes, the impact of astrocytic dysfunction on neuroplasticity, and the effect of some antidepressants on astrocyte reactivity. Recent evidence suggests that targeting astrocyte-related signaling pathways, particularly the balance between different astrocytic phenotypes, could offer promising evidence for therapeutic strategies for affective disorders. Therefore, a deeper understanding of astrocyte biology may open the way to innovative treatments aimed at mitigating depressive symptoms by impacting both neuroinflammation and imbalances in neuroplasticity. |
| format | Article |
| id | doaj-art-786f7a2aae8948a7af956c902c699b86 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-786f7a2aae8948a7af956c902c699b862024-11-22T04:35:24ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-11-011810.3389/fncel.2024.15045551504555Neuroinflammation and major depressive disorder: astrocytes at the crossroadsMelissa Puentes-Orozco0Melissa Puentes-Orozco1Sonia L. Albarracin2María Marcela Velásquez3Departamento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Bogotá, ColombiaInstituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, ColombiaDepartamento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Bogotá, ColombiaInstituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, ColombiaMajor depressive disorder is a complex and multifactorial condition, increasingly linked to neuroinflammation and astrocytic dysfunction. Astrocytes, along with other glial cells, beyond their classic functions in maintaining brain homeostasis, play a crucial role in regulating neuroinflammation and neuroplasticity, key processes in the pathophysiology of depression. This mini-review explores the involvement of astrocytes in depression emphasizing their mediation in neuroinflammation processes, the impact of astrocytic dysfunction on neuroplasticity, and the effect of some antidepressants on astrocyte reactivity. Recent evidence suggests that targeting astrocyte-related signaling pathways, particularly the balance between different astrocytic phenotypes, could offer promising evidence for therapeutic strategies for affective disorders. Therefore, a deeper understanding of astrocyte biology may open the way to innovative treatments aimed at mitigating depressive symptoms by impacting both neuroinflammation and imbalances in neuroplasticity.https://www.frontiersin.org/articles/10.3389/fncel.2024.1504555/fullmajor depressive disorderastrocytesneuroinflammationantidepressantsneuroplasticity |
| spellingShingle | Melissa Puentes-Orozco Melissa Puentes-Orozco Sonia L. Albarracin María Marcela Velásquez Neuroinflammation and major depressive disorder: astrocytes at the crossroads Frontiers in Cellular Neuroscience major depressive disorder astrocytes neuroinflammation antidepressants neuroplasticity |
| title | Neuroinflammation and major depressive disorder: astrocytes at the crossroads |
| title_full | Neuroinflammation and major depressive disorder: astrocytes at the crossroads |
| title_fullStr | Neuroinflammation and major depressive disorder: astrocytes at the crossroads |
| title_full_unstemmed | Neuroinflammation and major depressive disorder: astrocytes at the crossroads |
| title_short | Neuroinflammation and major depressive disorder: astrocytes at the crossroads |
| title_sort | neuroinflammation and major depressive disorder astrocytes at the crossroads |
| topic | major depressive disorder astrocytes neuroinflammation antidepressants neuroplasticity |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1504555/full |
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