<i>In Silico</i> Discovery and Evaluation of Inhibitors of the SARS-CoV-2 Spike Protein–HSPA8 Complex Towards Developing COVID-19 Therapeutic Drugs

<i>In Silico</i> Discovery and Evaluation of Inhibitors of the SARS-CoV-2 Spike Protein–HSPA8 Complex Towards Developing COVID-19 Therapeutic Drugs

The SARS-CoV-2 spike protein is pivotal in the COVID-19 virus’s life cycle, facilitating viral attachment to host cells. It is believed that targeting this viral protein could be key to developing effective COVID-19 prophylactics. Using in silico techniques, this study sought to virtually screen for...

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Bibliographic Details
Main Authors: Liberty T. Navhaya, Thabe M. Matsebatlela, Mokgerwa Z. Monama, Xolani H. Makhoba
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Viruses
Subjects:
COVID-19
SARS-CoV-2 spike protein
molecular chaperone
HSPA8–spike protein complex
small molecules
drug discovery
Online Access:https://www.mdpi.com/1999-4915/16/11/1726
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