The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer
Introduction: Peripheral counts of neutrophils and lymphocytes and their changes have been associated with disease prognosis in various malignancies. While several studies have investigated the changes and clinical implications of the peripheral blood neutrophil to lymphocyte ratio (NLR) in cervical...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2025-08-01
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| Series: | İstanbul Medical Journal |
| Subjects: | |
| Online Access: | https://www.istanbulmedicaljournal.org/articles/the-relationship-between-changes-in-the-neutrophil-lymphocyte-ratio-nlr-and-radiological-progression-in-cervical-cancer/doi/imj.galenos.2025.59254 |
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| Summary: | Introduction: Peripheral counts of neutrophils and lymphocytes and their changes have been associated with disease prognosis in various malignancies. While several studies have investigated the changes and clinical implications of the peripheral blood neutrophil to lymphocyte ratio (NLR) in cervical cancer, the prognostic value of NLR, in locally advanced cervical cancer remains unclear.
Methods: A retrospective analysis of cervical cancer patients who received definitive chemoradiotherapy (CRT) was carried out. NLR values were identified pre-CRT and post-CRT, and changes in these values were calculated. We assessed the relationship between changes in the NLR and clinicopathological features and disease prognosis.
Results: A total of eighty-five patients with locally advanced cervical cancer who received CRT were analyzed in this study. The rate of decrease in NLR in patients with progression was 22.2%, while in patients without progression was 17.2%. The rate of increase in NLR in patients with progression was 77.8%, while in patients without progression it was 82.8%. Higher or lower NLR levels were not found to have a significant relationship with disease progression (p=0.584).
Conclusion: The impact of changes in NLR on the prognosis of cervical cancer patients needs further validation in multicenter studies. |
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| ISSN: | 2619-9793 2148-094X |