Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway

Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway

Abstract Background Despite the existence of promising outcomes from standard 2D culture systems, these data are not completely akin to in vivo tumor parenchyma. Therefore, the development and fabrication of various 3D culture systems can in part mimic intricate cell-to-cell interaction within the r...

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Main Authors: Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Colorectal adenocarcinoma cancer
Tumoroids
Metformin
Autophagy
Apoptosis
Tumoricidal effects
Online Access:https://doi.org/10.1186/s13287-025-04174-z
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