Effects of fish oil supplementation on bone turnover markers in depression: a pilot study
Background and objectiveThere is a close correlation between bone loss, depression, and antidepressants. N-3 PUFA supplementation has been considered an effective add-on therapeutic approach in ameliorating bone loss and relieving depression. However, the adjunctive effect of n-3 PUFA on bone metabo...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1464526/full |
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| author | Feifei Wang Feifei Wang Hui Yuan Kun Jin Hui Tang Jimin Guo Chuan-Yue Wang Chuan-Yue Wang Jindong Chen Fang Dong Fang Dong Lu Wang Lu Wang Lu Wang |
| author_facet | Feifei Wang Feifei Wang Hui Yuan Kun Jin Hui Tang Jimin Guo Chuan-Yue Wang Chuan-Yue Wang Jindong Chen Fang Dong Fang Dong Lu Wang Lu Wang Lu Wang |
| author_sort | Feifei Wang |
| collection | DOAJ |
| description | Background and objectiveThere is a close correlation between bone loss, depression, and antidepressants. N-3 PUFA supplementation has been considered an effective add-on therapeutic approach in ameliorating bone loss and relieving depression. However, the adjunctive effect of n-3 PUFA on bone metabolism in participants with depression is still unknown. This is a pilot study to investigate the dynamics of bone metabolism in depression and evaluate the efficacy of fish oil on bone loss in depression.MethodsIn this study, we focused on the change of bone turnover markers in depression, the effect of n-3 PUFA supplementation on bone turnover markers, and its association with clinical characteristics. A case–control study and a secondary analysis of a previously published randomized clinical trial (NCT03295708) that evaluates the efficacy of n-3 PUFA supplementation in venlafaxine-treated depressed participants have been included.ResultsThe levels of PINP (z = −2.233, p = 0.026) in depressed participants were significantly increased compared with healthy controls at baseline. The secondary analysis has shown significant differences exited on CTX (χ2 = 4.848, p = 0.028) and OSTEOC (χ2 = 6.178, p = 0.013) between n-3 PUFA and placebo group. The levels of CTX and OSTEOC (p < 0.05) significantly decreased in the placebo group, which indicates that venlafaxine treatment reduces both bone formation and resorption markers. While the levels of OSTEOC and PINP were increased in the n-3 PUFA group (p < 0.05). Moreover, the change in bone turnover markers showed consistency with clinical symptomatic outcomes.ConclusionParticipants with first-diagnosed, drug-naïve depression show active bone formation. Venlafaxine decreases bone remodeling, while n-3 PUFA increases bone formation, bringing light to preventing and treating bone loss in depression.Clinical trial registrationClinicalTrials.gov, NCT03295708. |
| format | Article |
| id | doaj-art-77d4d2b6b8384fb1956f6e1c6b7163d5 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-77d4d2b6b8384fb1956f6e1c6b7163d52024-12-12T12:45:47ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-12-011110.3389/fnut.2024.14645261464526Effects of fish oil supplementation on bone turnover markers in depression: a pilot studyFeifei Wang0Feifei Wang1Hui Yuan2Kun Jin3Hui Tang4Jimin Guo5Chuan-Yue Wang6Chuan-Yue Wang7Jindong Chen8Fang Dong9Fang Dong10Lu Wang11Lu Wang12Lu Wang13The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaCollege of Materials Sciences and Engineering, Beijing University of Chemical Technology, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, and China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaBackground and objectiveThere is a close correlation between bone loss, depression, and antidepressants. N-3 PUFA supplementation has been considered an effective add-on therapeutic approach in ameliorating bone loss and relieving depression. However, the adjunctive effect of n-3 PUFA on bone metabolism in participants with depression is still unknown. This is a pilot study to investigate the dynamics of bone metabolism in depression and evaluate the efficacy of fish oil on bone loss in depression.MethodsIn this study, we focused on the change of bone turnover markers in depression, the effect of n-3 PUFA supplementation on bone turnover markers, and its association with clinical characteristics. A case–control study and a secondary analysis of a previously published randomized clinical trial (NCT03295708) that evaluates the efficacy of n-3 PUFA supplementation in venlafaxine-treated depressed participants have been included.ResultsThe levels of PINP (z = −2.233, p = 0.026) in depressed participants were significantly increased compared with healthy controls at baseline. The secondary analysis has shown significant differences exited on CTX (χ2 = 4.848, p = 0.028) and OSTEOC (χ2 = 6.178, p = 0.013) between n-3 PUFA and placebo group. The levels of CTX and OSTEOC (p < 0.05) significantly decreased in the placebo group, which indicates that venlafaxine treatment reduces both bone formation and resorption markers. While the levels of OSTEOC and PINP were increased in the n-3 PUFA group (p < 0.05). Moreover, the change in bone turnover markers showed consistency with clinical symptomatic outcomes.ConclusionParticipants with first-diagnosed, drug-naïve depression show active bone formation. Venlafaxine decreases bone remodeling, while n-3 PUFA increases bone formation, bringing light to preventing and treating bone loss in depression.Clinical trial registrationClinicalTrials.gov, NCT03295708.https://www.frontiersin.org/articles/10.3389/fnut.2024.1464526/fullmajor depressive disordern-3 PUFAbone formationbone resorptionbone loss |
| spellingShingle | Feifei Wang Feifei Wang Hui Yuan Kun Jin Hui Tang Jimin Guo Chuan-Yue Wang Chuan-Yue Wang Jindong Chen Fang Dong Fang Dong Lu Wang Lu Wang Lu Wang Effects of fish oil supplementation on bone turnover markers in depression: a pilot study Frontiers in Nutrition major depressive disorder n-3 PUFA bone formation bone resorption bone loss |
| title | Effects of fish oil supplementation on bone turnover markers in depression: a pilot study |
| title_full | Effects of fish oil supplementation on bone turnover markers in depression: a pilot study |
| title_fullStr | Effects of fish oil supplementation on bone turnover markers in depression: a pilot study |
| title_full_unstemmed | Effects of fish oil supplementation on bone turnover markers in depression: a pilot study |
| title_short | Effects of fish oil supplementation on bone turnover markers in depression: a pilot study |
| title_sort | effects of fish oil supplementation on bone turnover markers in depression a pilot study |
| topic | major depressive disorder n-3 PUFA bone formation bone resorption bone loss |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1464526/full |
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