Thymic Microenvironment Remodeling in Cancer Cachexia as a Determinant of Checkpoint Inhibitor Efficacy and Toxicity

Thymic Microenvironment Remodeling in Cancer Cachexia as a Determinant of Checkpoint Inhibitor Efficacy and Toxicity

ABSTRACT Background The discovery of immune checkpoints links autoimmunity and cancer, with thymus atrophy reportedly causing autoimmune multiorgan inflammation. The impact of cancer cachexia on thymic involution and its clinical significance remains unclear. This study aimed to investigate this eff...

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Main Authors: Run‐Kai Huang, Yan‐Fang Xing, Xiang‐Yuan Wu, Zhao‐Hui Shi, Li Wei, Xiao‐Tong Lv, Lin‐Jiao Peng, Xiu‐Qing Pang, Qin‐Tai Yang, Xing Li
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
cancer cachexia
immune checkpoint inhibitors
T cell negative selection
thymus involution
thymus medullary fibroblast
Online Access:https://doi.org/10.1002/jcsm.13874
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https://doi.org/10.1002/jcsm.13874

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