Dendritic cell membrane-based DCsLipo@MnO2@siCTLA4@PD-1α nanomedicine for the treatment of Lynch syndrome-related colorectal cancer

Dendritic cell membrane-based DCsLipo@MnO2@siCTLA4@PD-1α nanomedicine for the treatment of Lynch syndrome-related colorectal cancer

Background: The immune checkpoint inhibitor (ICI) PD-1α can effectively treat Lynch syndrome (LS)-associated colorectal cancer (CRC) (LS-CRC). In some cases, LS-CRC is not sensitive to ICIs. Dendritic cell (DC)-based hybrid membrane nanoparticles have great potential to upgrade the efficacy of ICIs,...

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Bibliographic Details
Main Authors: Wenjin Zhong, Pengcheng Wang, Jintian Wang, Yuejia Zhu, Liquan Chen, Yilong Qian, Xiang Huang, Kai Ye
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
PD-1α
Dendritic cells
Hybrid membrane
Nanomedicine
Lynch syndrome-related colorectal cancer
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006155
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