Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma
Sickle cell disease (SCD) is a devastating hemolytic disease, marked by recurring bouts of painful vaso-occlusion, leading to tissue damage from ischemia/reperfusion pathophysiology. Central to this process are oxidative stress, endothelial cell activation, inflammation, and vascular dysfunction. Th...
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Main Authors: | Joan D. Beckman, Ping Zhang, Julia Nguyen, Robert P. Hebbel, Gregory M. Vercellotti, John D. Belcher |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2024-12-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493904/full |
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