Modelling hepatocellular carcinoma microenvironment phenotype to evaluate drug efficacy

Modelling hepatocellular carcinoma microenvironment phenotype to evaluate drug efficacy

Abstract Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. Treating HCC is challenging because of the poor drug effectiveness and the lack of tools to predict patient responses. To resolve these issues, we established a patient-centric spheroid model us...

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Bibliographic Details
Main Authors: Sara Cherradi, Salomé Roux, Marie Dupuy, Séverine Tabone-Eglinger, Edouard Tuaillon, Marianne Ziol, Eric Assenat, Hong Tuan Duong
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Patient-centric spheroid model
Hepatocellular carcinoma
Targeted therapy
Tyrosine kinase inhibitors
Prediction of clinical outcomes
Online Access:https://doi.org/10.1038/s41598-024-84304-4
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