Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer
Abstract Breast cancer (BC) is the most frequently diagnosed malignancy among women. It is characterized by a high level of heterogeneity that emerges from the interaction of several cellular and soluble components in the tumor microenvironment (TME), such as cytokines, tumor cells and tumor-associa...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13046-024-03218-1 |
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| author | Ali Mussa Nor Hayati Ismail Mahasin Hamid Mohammad A. I. Al-Hatamleh Anthony Bragoli Khalid Hajissa Noor Fatmawati Mokhtar Rohimah Mohamud Vuk Uskoković Rosline Hassan |
| author_facet | Ali Mussa Nor Hayati Ismail Mahasin Hamid Mohammad A. I. Al-Hatamleh Anthony Bragoli Khalid Hajissa Noor Fatmawati Mokhtar Rohimah Mohamud Vuk Uskoković Rosline Hassan |
| author_sort | Ali Mussa |
| collection | DOAJ |
| description | Abstract Breast cancer (BC) is the most frequently diagnosed malignancy among women. It is characterized by a high level of heterogeneity that emerges from the interaction of several cellular and soluble components in the tumor microenvironment (TME), such as cytokines, tumor cells and tumor-associated immune cells. Tumor necrosis factor (TNF) receptor 2 (TNFR2) appears to play a significant role in microenvironmental regulation, tumor progression, immune evasion, drug resistance, and metastasis of many types of cancer, including BC. However, the significance of TNFR2 in BC biology is not fully understood. This review provides an overview of TNFR2 biology, detailing its activation and its interactions with important signaling pathways in the TME (e.g., NF-κB, MAPK, and PI3K/Akt pathways). We discuss potential therapeutic strategies targeting TNFR2, with the aim of enhancing the antitumor immune response to BC. This review provides insights into role of TNFR2 as a major immune checkpoint for the future treatment of patients with BC. |
| format | Article |
| id | doaj-art-77178463ef514002975c52b926c0e72e |
| institution | Kabale University |
| issn | 1756-9966 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-77178463ef514002975c52b926c0e72e2024-12-01T12:50:27ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662024-11-0143115310.1186/s13046-024-03218-1Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancerAli Mussa0Nor Hayati Ismail1Mahasin Hamid2Mohammad A. I. Al-Hatamleh3Anthony Bragoli4Khalid Hajissa5Noor Fatmawati Mokhtar6Rohimah Mohamud7Vuk Uskoković8Rosline Hassan9Department of Haematology, School of Medical Sciences, Universiti Sains MalaysiaDepartment of Haematology, School of Medical Sciences, Universiti Sains MalaysiaDepartment of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan ProvinceDivision of Hematology and Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of PittsburghDepartment of Immunology, University of PittsburghDepartment of Zoology, Faculty of Science and Technology, Omdurman Islamic UniversityInstitute for Research in Molecular Medicine (iNFORMM), Universiti Sains MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains MalaysiaTardigradeNano LLCDepartment of Haematology, School of Medical Sciences, Universiti Sains MalaysiaAbstract Breast cancer (BC) is the most frequently diagnosed malignancy among women. It is characterized by a high level of heterogeneity that emerges from the interaction of several cellular and soluble components in the tumor microenvironment (TME), such as cytokines, tumor cells and tumor-associated immune cells. Tumor necrosis factor (TNF) receptor 2 (TNFR2) appears to play a significant role in microenvironmental regulation, tumor progression, immune evasion, drug resistance, and metastasis of many types of cancer, including BC. However, the significance of TNFR2 in BC biology is not fully understood. This review provides an overview of TNFR2 biology, detailing its activation and its interactions with important signaling pathways in the TME (e.g., NF-κB, MAPK, and PI3K/Akt pathways). We discuss potential therapeutic strategies targeting TNFR2, with the aim of enhancing the antitumor immune response to BC. This review provides insights into role of TNFR2 as a major immune checkpoint for the future treatment of patients with BC.https://doi.org/10.1186/s13046-024-03218-1Immune checkpointImmunosuppressive TMETNFTNFRSF1BCD120b |
| spellingShingle | Ali Mussa Nor Hayati Ismail Mahasin Hamid Mohammad A. I. Al-Hatamleh Anthony Bragoli Khalid Hajissa Noor Fatmawati Mokhtar Rohimah Mohamud Vuk Uskoković Rosline Hassan Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer Journal of Experimental & Clinical Cancer Research Immune checkpoint Immunosuppressive TME TNF TNFRSF1B CD120b |
| title | Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer |
| title_full | Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer |
| title_fullStr | Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer |
| title_full_unstemmed | Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer |
| title_short | Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer |
| title_sort | understanding the role of tnfr2 signaling in the tumor microenvironment of breast cancer |
| topic | Immune checkpoint Immunosuppressive TME TNF TNFRSF1B CD120b |
| url | https://doi.org/10.1186/s13046-024-03218-1 |
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