Multi-omics evaluation of clinical-grade human umbilical cord-derived mesenchymal stem cells in synergistic improvement of aging related disorders in a senescence-accelerated mouse model

Multi-omics evaluation of clinical-grade human umbilical cord-derived mesenchymal stem cells in synergistic improvement of aging related disorders in a senescence-accelerated mouse model

Abstract Background The prevalence of age-related disorders, particularly in neurological and cardiovascular systems, is an increasing global health concern. Mesenchymal stem cell (MSC) therapy, particularly using human umbilical cord-derived MSCs (HUCMSCs), has shown promise in mitigating these dis...

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Bibliographic Details
Main Authors: Jiabian Lian, Lu Xia, Guohao Wang, Weijing Wu, Ping Yi, Meilin Li, Xufeng Su, Yushuo Chen, Xun Li, Fei Dou, Zhanxiang Wang
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Stem Cell Research & Therapy
Subjects:
Faecal microbiome
Metabolomics
Human umbilical cord mesenchymal stem cells
Senescence-accelerated mouse model
Aging
DNA breaks
Online Access:https://doi.org/10.1186/s13287-024-03986-9
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https://doi.org/10.1186/s13287-024-03986-9

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