A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report
Abstract Background Stutzerimonas is a recently proposed genus comprising strains formerly classified as Pseudomonas stutzeri. The genus includes at least 16 identified species. Stutzerimonas nitrititolerans, previously known as Pseudomonas nitrititolerans, was initially isolated from a bioreactor....
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BMC
2025-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10440-5 |
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| author | Kohei Hasegawa Kenya Murata Yuki Suzuki Yoshihiko Ogawa Hisakazu Yano |
| author_facet | Kohei Hasegawa Kenya Murata Yuki Suzuki Yoshihiko Ogawa Hisakazu Yano |
| author_sort | Kohei Hasegawa |
| collection | DOAJ |
| description | Abstract Background Stutzerimonas is a recently proposed genus comprising strains formerly classified as Pseudomonas stutzeri. The genus includes at least 16 identified species. Stutzerimonas nitrititolerans, previously known as Pseudomonas nitrititolerans, was initially isolated from a bioreactor. Only one case of human infection has been reported to date, and its pathogenicity remains unknown. Case presentation We present a case of community-acquired S. nitrititolerans bacteremia in a 77-year-old Japanese man with a sacral pressure ulcer. On admission for cerebral infarction, empirical ampicillin/sulbactam was administered because of an infected sacral pressure ulcer. Blood cultures revealed Gram-negative bacilli. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry was unable to identify the species, but 16 S ribosomal RNA gene sequencing identified the isolate NR5426 as S. nitrititolerans. Despite negative results for common carbapenem-resistance genes, the strain showed possible metallo-beta-lactamase production. The patient was treated with piperacillin/tazobactam and recovered. Conclusions This case confirms that S. nitrititolerans can cause infection in humans and highlights the antimicrobial susceptibility profile and the treatment strategy for infections caused by this rare bacterium. Further studies are required to determine its resistance mechanisms and the clinical implications. |
| format | Article |
| id | doaj-art-76e47c1d1a8d43d69ceae27a45609e54 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-76e47c1d1a8d43d69ceae27a45609e542025-01-12T12:09:30ZengBMCBMC Infectious Diseases1471-23342025-01-012511610.1186/s12879-025-10440-5A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case reportKohei Hasegawa0Kenya Murata1Yuki Suzuki2Yoshihiko Ogawa3Hisakazu Yano4Department of Infectious Diseases, Sakai City Medical CenterDepartment of Infectious Diseases, Sakai City Medical CenterDepartment of Microbiology and Infectious Diseases, Nara Medical UniversityDepartment of Infectious Diseases, Sakai City Medical CenterDepartment of Microbiology and Infectious Diseases, Nara Medical UniversityAbstract Background Stutzerimonas is a recently proposed genus comprising strains formerly classified as Pseudomonas stutzeri. The genus includes at least 16 identified species. Stutzerimonas nitrititolerans, previously known as Pseudomonas nitrititolerans, was initially isolated from a bioreactor. Only one case of human infection has been reported to date, and its pathogenicity remains unknown. Case presentation We present a case of community-acquired S. nitrititolerans bacteremia in a 77-year-old Japanese man with a sacral pressure ulcer. On admission for cerebral infarction, empirical ampicillin/sulbactam was administered because of an infected sacral pressure ulcer. Blood cultures revealed Gram-negative bacilli. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry was unable to identify the species, but 16 S ribosomal RNA gene sequencing identified the isolate NR5426 as S. nitrititolerans. Despite negative results for common carbapenem-resistance genes, the strain showed possible metallo-beta-lactamase production. The patient was treated with piperacillin/tazobactam and recovered. Conclusions This case confirms that S. nitrititolerans can cause infection in humans and highlights the antimicrobial susceptibility profile and the treatment strategy for infections caused by this rare bacterium. Further studies are required to determine its resistance mechanisms and the clinical implications.https://doi.org/10.1186/s12879-025-10440-5Stutzerimonas nitrititolerans bacteremia16S rRNA sequencingNon-fermenting Gram-negative bacilli |
| spellingShingle | Kohei Hasegawa Kenya Murata Yuki Suzuki Yoshihiko Ogawa Hisakazu Yano A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report BMC Infectious Diseases Stutzerimonas nitrititolerans bacteremia 16S rRNA sequencing Non-fermenting Gram-negative bacilli |
| title | A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report |
| title_full | A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report |
| title_fullStr | A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report |
| title_full_unstemmed | A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report |
| title_short | A Japanese man with community-onset carbapenem-resistant Stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer: a case report |
| title_sort | japanese man with community onset carbapenem resistant stutzerimonas nitrititolerans bacteremia and a sacral pressure ulcer a case report |
| topic | Stutzerimonas nitrititolerans bacteremia 16S rRNA sequencing Non-fermenting Gram-negative bacilli |
| url | https://doi.org/10.1186/s12879-025-10440-5 |
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