Methodological review to develop a list of bias items for adaptive clinical trials: Protocol and rationale.

Methodological review to develop a list of bias items for adaptive clinical trials: Protocol and rationale.

<h4>Background</h4>Randomized-clinical trials (RCTs) are the gold-standard for comparing health care interventions, but can be limited by early termination, feasibility issues, and prolonged time to trial reporting. Adaptive clinical trials (ACTs), which are defined by pre-planned modifi...

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Main Authors: Phillip Staibano, Tyler McKechnie, Alex Thabane, Daniel Olteanu, Keean Nanji, Han Zhang, Carole Lunny, Michael Au, Michael K Gupta, Jesse D Pasternak, Sameer Parpia, Jem Ted Young, Mohit Bhandari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0303315
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