Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence?
A 59-year-old male presented with syncope and nonsustained ventricular tachycardia and was diagnosed to have hypertrophic obstructive cardiomyopathy. He underwent dual-chamber implantable converter defibrillator (ICD) insertion. Following ICD insertion, in view of some red flags, routine cardiac mag...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
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| Online Access: | https://journals.lww.com/10.4103/jiae.jiae_3_24 |
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| author | Madhu Shukla Jagdish Chander Mohan |
| author_facet | Madhu Shukla Jagdish Chander Mohan |
| author_sort | Madhu Shukla |
| collection | DOAJ |
| description | A 59-year-old male presented with syncope and nonsustained ventricular tachycardia and was diagnosed to have hypertrophic obstructive cardiomyopathy. He underwent dual-chamber implantable converter defibrillator (ICD) insertion. Following ICD insertion, in view of some red flags, routine cardiac magnetic resonance imaging was performed, which showed biventricular hypertrophy, diffuse subendocardial gadolinium enhancement of both the ventricles, prolonged T1 and T2, and left ventricular extracellular volume fraction of 50%. A pyrophosphate scan of the heart was strongly positive both at 1 and 3 h intervals. M-band was observed on plasma protein electrophoresis. Serum and urinary immunofixation studies suggested lambda light-chain gammopathy. Multiparametric flow cytometry of the bone marrow aspirate revealed 20% plasma cells immunophenotyped to produce only light-chain immunoglobulins. The patient is on specific chemotherapy for the past 7 months and is asymptomatic. |
| format | Article |
| id | doaj-art-76bfdff74fbc47b698a93e1e7c0dc1ee |
| institution | Kabale University |
| issn | 2543-1463 2543-1471 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
| spelling | doaj-art-76bfdff74fbc47b698a93e1e7c0dc1ee2025-01-12T10:19:14ZengWolters Kluwer Medknow PublicationsJournal of the Indian Academy of Echocardiography & Cardiovascular Imaging2543-14632543-14712024-07-018317718010.4103/jiae.jiae_3_24Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence?Madhu ShuklaJagdish Chander MohanA 59-year-old male presented with syncope and nonsustained ventricular tachycardia and was diagnosed to have hypertrophic obstructive cardiomyopathy. He underwent dual-chamber implantable converter defibrillator (ICD) insertion. Following ICD insertion, in view of some red flags, routine cardiac magnetic resonance imaging was performed, which showed biventricular hypertrophy, diffuse subendocardial gadolinium enhancement of both the ventricles, prolonged T1 and T2, and left ventricular extracellular volume fraction of 50%. A pyrophosphate scan of the heart was strongly positive both at 1 and 3 h intervals. M-band was observed on plasma protein electrophoresis. Serum and urinary immunofixation studies suggested lambda light-chain gammopathy. Multiparametric flow cytometry of the bone marrow aspirate revealed 20% plasma cells immunophenotyped to produce only light-chain immunoglobulins. The patient is on specific chemotherapy for the past 7 months and is asymptomatic.https://journals.lww.com/10.4103/jiae.jiae_3_24cardiac amyloidosishypertrophic cardiomyopathysyncope |
| spellingShingle | Madhu Shukla Jagdish Chander Mohan Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging cardiac amyloidosis hypertrophic cardiomyopathy syncope |
| title | Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? |
| title_full | Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? |
| title_fullStr | Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? |
| title_full_unstemmed | Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? |
| title_short | Cardiac Amyloidosis Masquerading as Hypertrophic Obstructive Cardiomyopathy: Co-existence or Coincidence? |
| title_sort | cardiac amyloidosis masquerading as hypertrophic obstructive cardiomyopathy co existence or coincidence |
| topic | cardiac amyloidosis hypertrophic cardiomyopathy syncope |
| url | https://journals.lww.com/10.4103/jiae.jiae_3_24 |
| work_keys_str_mv | AT madhushukla cardiacamyloidosismasqueradingashypertrophicobstructivecardiomyopathycoexistenceorcoincidence AT jagdishchandermohan cardiacamyloidosismasqueradingashypertrophicobstructivecardiomyopathycoexistenceorcoincidence |