Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging
18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease. 18F-NaF uptake colocalizes to high-risk and ruptured atherosclerotic plaques. Most recently, 18F-NaF c...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-01-01
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| Series: | Molecular Imaging |
| Online Access: | http://dx.doi.org/10.1155/2021/8849429 |
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| author | Jacek Kwiecinski Martin Lyngby Lassen Piotr J. Slomka |
| author_facet | Jacek Kwiecinski Martin Lyngby Lassen Piotr J. Slomka |
| author_sort | Jacek Kwiecinski |
| collection | DOAJ |
| description | 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease. 18F-NaF uptake colocalizes to high-risk and ruptured atherosclerotic plaques. Most recently, 18F-NaF coronary uptake was shown to be a robust and independent predictor of myocardial infarction in patients with advanced coronary artery disease. In this review, we provide an overview of the advances in coronary 18F-NaF imaging. In particular, we discuss the recently developed and validated motion correction techniques which address heart contractions, tidal breathing, and patient repositioning during the prolonged PET acquisitions. Additionally, we discuss a novel quantification approach—the coronary microcalcification activity (which has been inspired by the widely employed method in oncology total active tumor volume measurement). This new method provides a single number encompassing 18F-NaF activity within the entire coronary vasculature rather than just information regarding a single area of most intense tracer uptake. |
| format | Article |
| id | doaj-art-76a98a05adfa4c059dab90c59e9bda09 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-76a98a05adfa4c059dab90c59e9bda092025-01-02T02:58:06ZengSAGE PublishingMolecular Imaging1536-01212021-01-01202110.1155/2021/88494298849429Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary ImagingJacek Kwiecinski0Martin Lyngby Lassen1Piotr J. Slomka2Department of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USADepartment of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USADepartment of Imaging (Division of Nuclear Medicine), Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease. 18F-NaF uptake colocalizes to high-risk and ruptured atherosclerotic plaques. Most recently, 18F-NaF coronary uptake was shown to be a robust and independent predictor of myocardial infarction in patients with advanced coronary artery disease. In this review, we provide an overview of the advances in coronary 18F-NaF imaging. In particular, we discuss the recently developed and validated motion correction techniques which address heart contractions, tidal breathing, and patient repositioning during the prolonged PET acquisitions. Additionally, we discuss a novel quantification approach—the coronary microcalcification activity (which has been inspired by the widely employed method in oncology total active tumor volume measurement). This new method provides a single number encompassing 18F-NaF activity within the entire coronary vasculature rather than just information regarding a single area of most intense tracer uptake.http://dx.doi.org/10.1155/2021/8849429 |
| spellingShingle | Jacek Kwiecinski Martin Lyngby Lassen Piotr J. Slomka Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging Molecular Imaging |
| title | Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging |
| title_full | Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging |
| title_fullStr | Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging |
| title_full_unstemmed | Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging |
| title_short | Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging |
| title_sort | advances in quantitative analysis of 18f sodium fluoride coronary imaging |
| url | http://dx.doi.org/10.1155/2021/8849429 |
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