Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing
<b>Background</b>: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to inf...
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MDPI AG
2024-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/11/1429 |
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| author | Zhao Chen Man Zhe Wenting Wu Peiyun Yu Yuzhen Xiao Hao Liu Ming Liu Zhou Xiang Fei Xing |
| author_facet | Zhao Chen Man Zhe Wenting Wu Peiyun Yu Yuzhen Xiao Hao Liu Ming Liu Zhou Xiang Fei Xing |
| author_sort | Zhao Chen |
| collection | DOAJ |
| description | <b>Background</b>: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to infection. <b>Methods</b>: In this research, we created an injectable hydrogel wound dressing formulated from gelatin methacryloyl (GelMA) that encapsulates quercetin-loaded zeolitic imidazolate framework-8 (Qu@ZIF-8) nanoparticles. Next, its ability to promote skin wound healing was validated through in vitro experiments and animal studies. <b>Results</b>: Research conducted both in vitro and in vivo indicated that this hydrogel dressing effectively mitigates inflammation, inhibits bacterial growth, and promotes angiogenesis and collagen synthesis, thus facilitating a safe and efficient healing process for wounds. <b>Conclusions</b>: This cutting-edge scaffold system provides a novel strategy for wound repair and demonstrates significant potential for clinical applications. |
| format | Article |
| id | doaj-art-768c9698065f4ff2ac4a2a7c55c5e023 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-768c9698065f4ff2ac4a2a7c55c5e0232024-11-26T18:17:58ZengMDPI AGPharmaceutics1999-49232024-11-011611142910.3390/pharmaceutics16111429Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound HealingZhao Chen0Man Zhe1Wenting Wu2Peiyun Yu3Yuzhen Xiao4Hao Liu5Ming Liu6Zhou Xiang7Fei Xing8Department of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, ChinaAnimal Experiment Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pediatric Surgery, Division of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, ChinaLIMES Institute, Department of Molecular Brain Physiology and Behavior, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, GermanyInstitute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, ChinaDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pediatric Surgery, Division of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China<b>Background</b>: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to infection. <b>Methods</b>: In this research, we created an injectable hydrogel wound dressing formulated from gelatin methacryloyl (GelMA) that encapsulates quercetin-loaded zeolitic imidazolate framework-8 (Qu@ZIF-8) nanoparticles. Next, its ability to promote skin wound healing was validated through in vitro experiments and animal studies. <b>Results</b>: Research conducted both in vitro and in vivo indicated that this hydrogel dressing effectively mitigates inflammation, inhibits bacterial growth, and promotes angiogenesis and collagen synthesis, thus facilitating a safe and efficient healing process for wounds. <b>Conclusions</b>: This cutting-edge scaffold system provides a novel strategy for wound repair and demonstrates significant potential for clinical applications.https://www.mdpi.com/1999-4923/16/11/1429wound healinghydrogel wound dressingsantibacterialimmunomodulationangiogenesis |
| spellingShingle | Zhao Chen Man Zhe Wenting Wu Peiyun Yu Yuzhen Xiao Hao Liu Ming Liu Zhou Xiang Fei Xing Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing Pharmaceutics wound healing hydrogel wound dressings antibacterial immunomodulation angiogenesis |
| title | Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing |
| title_full | Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing |
| title_fullStr | Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing |
| title_full_unstemmed | Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing |
| title_short | Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing |
| title_sort | injectable photocrosslinked hydrogel dressing encapsulating quercetin loaded zeolitic imidazolate framework 8 for skin wound healing |
| topic | wound healing hydrogel wound dressings antibacterial immunomodulation angiogenesis |
| url | https://www.mdpi.com/1999-4923/16/11/1429 |
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