The possible impact of pre-transfusion laboratory interference
Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused. Objective: To describe a clinical case treated with plasmapheresis and immunosuppression. Methods: Descriptive study of a clinical case of a 55-yea...
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Language: | English |
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Instituto Politécnico de Viseu
2024-12-01
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Series: | Millenium |
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Online Access: | https://revistas.rcaap.pt/millenium/article/view/36799 |
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author | Luís Moura Liliana Fonseca Emanuel Rodrigues Rui Lobo Arnaldo Brito Mariana Costa |
author_facet | Luís Moura Liliana Fonseca Emanuel Rodrigues Rui Lobo Arnaldo Brito Mariana Costa |
author_sort | Luís Moura |
collection | DOAJ |
description |
Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused.
Objective: To describe a clinical case treated with plasmapheresis and immunosuppression.
Methods: Descriptive study of a clinical case of a 55-year-old man, hospitalized for rapidly progressive renal failure, treated with plasmapheresis and immunosuppression to reduce/remove the pathological immune component responsible for interfering with pre-transfusion tests. Daily monitoring of the clinical situation was carried out using laboratory tests of specific blood parameters.
Results: The decrease in antibody titters, due to the action of the immunosuppressants used in association with the TPE sessions, in addition to the clear clinical impact on the recovery of renal function, also made it possible to remove this interference and select the blood units more safely.
Conclusion: It is essential to develop methods that identify and remove pathological substances that could interfere with the compatibility of units to be transfused and, therefore, with transfusion safety.
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format | Article |
id | doaj-art-766646cba8a7400fbb3abc3f48f9cf8c |
institution | Kabale University |
issn | 0873-3015 1647-662X |
language | English |
publishDate | 2024-12-01 |
publisher | Instituto Politécnico de Viseu |
record_format | Article |
series | Millenium |
spelling | doaj-art-766646cba8a7400fbb3abc3f48f9cf8c2024-12-18T08:44:18ZengInstituto Politécnico de ViseuMillenium0873-30151647-662X2024-12-0116e10.29352/mill0216e.36799The possible impact of pre-transfusion laboratory interferenceLuís Moura0Liliana Fonseca1Emanuel Rodrigues2Rui Lobo3Arnaldo Brito4Mariana Costa5Unidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, Portugal Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused. Objective: To describe a clinical case treated with plasmapheresis and immunosuppression. Methods: Descriptive study of a clinical case of a 55-year-old man, hospitalized for rapidly progressive renal failure, treated with plasmapheresis and immunosuppression to reduce/remove the pathological immune component responsible for interfering with pre-transfusion tests. Daily monitoring of the clinical situation was carried out using laboratory tests of specific blood parameters. Results: The decrease in antibody titters, due to the action of the immunosuppressants used in association with the TPE sessions, in addition to the clear clinical impact on the recovery of renal function, also made it possible to remove this interference and select the blood units more safely. Conclusion: It is essential to develop methods that identify and remove pathological substances that could interfere with the compatibility of units to be transfused and, therefore, with transfusion safety. https://revistas.rcaap.pt/millenium/article/view/36799laboratory interference; therapeutic plasmapheresis; crossmatch; transfusion |
spellingShingle | Luís Moura Liliana Fonseca Emanuel Rodrigues Rui Lobo Arnaldo Brito Mariana Costa The possible impact of pre-transfusion laboratory interference Millenium laboratory interference; therapeutic plasmapheresis; crossmatch; transfusion |
title | The possible impact of pre-transfusion laboratory interference |
title_full | The possible impact of pre-transfusion laboratory interference |
title_fullStr | The possible impact of pre-transfusion laboratory interference |
title_full_unstemmed | The possible impact of pre-transfusion laboratory interference |
title_short | The possible impact of pre-transfusion laboratory interference |
title_sort | possible impact of pre transfusion laboratory interference |
topic | laboratory interference; therapeutic plasmapheresis; crossmatch; transfusion |
url | https://revistas.rcaap.pt/millenium/article/view/36799 |
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