The possible impact of pre-transfusion laboratory interference

Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused. Objective: To describe a clinical case treated with plasmapheresis and immunosuppression. Methods: Descriptive study of a clinical case of a 55-yea...

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Main Authors: Luís Moura, Liliana Fonseca, Emanuel Rodrigues, Rui Lobo, Arnaldo Brito, Mariana Costa
Format: Article
Language:English
Published: Instituto Politécnico de Viseu 2024-12-01
Series:Millenium
Subjects:
Online Access:https://revistas.rcaap.pt/millenium/article/view/36799
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author Luís Moura
Liliana Fonseca
Emanuel Rodrigues
Rui Lobo
Arnaldo Brito
Mariana Costa
author_facet Luís Moura
Liliana Fonseca
Emanuel Rodrigues
Rui Lobo
Arnaldo Brito
Mariana Costa
author_sort Luís Moura
collection DOAJ
description Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused. Objective: To describe a clinical case treated with plasmapheresis and immunosuppression. Methods: Descriptive study of a clinical case of a 55-year-old man, hospitalized for rapidly progressive renal failure, treated with plasmapheresis and immunosuppression to reduce/remove the pathological immune component responsible for interfering with pre-transfusion tests. Daily monitoring of the clinical situation was carried out using laboratory tests of specific blood parameters. Results: The decrease in antibody titters, due to the action of the immunosuppressants used in association with the TPE sessions, in addition to the clear clinical impact on the recovery of renal function, also made it possible to remove this interference and select the blood units more safely. Conclusion: It is essential to develop methods that identify and remove pathological substances that could interfere with the compatibility of units to be transfused and, therefore, with transfusion safety.
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institution Kabale University
issn 0873-3015
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language English
publishDate 2024-12-01
publisher Instituto Politécnico de Viseu
record_format Article
series Millenium
spelling doaj-art-766646cba8a7400fbb3abc3f48f9cf8c2024-12-18T08:44:18ZengInstituto Politécnico de ViseuMillenium0873-30151647-662X2024-12-0116e10.29352/mill0216e.36799The possible impact of pre-transfusion laboratory interferenceLuís Moura0Liliana Fonseca1Emanuel Rodrigues2Rui Lobo3Arnaldo Brito4Mariana Costa5Unidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, PortugalUnidade Local de Saúde Viseu Dão-Lafões, Viseu, Portugal Introduction: Pre-transfusion tests allow the detection of clinically significant antibodies and the prior compatibility of units to be transfused. Objective: To describe a clinical case treated with plasmapheresis and immunosuppression. Methods: Descriptive study of a clinical case of a 55-year-old man, hospitalized for rapidly progressive renal failure, treated with plasmapheresis and immunosuppression to reduce/remove the pathological immune component responsible for interfering with pre-transfusion tests. Daily monitoring of the clinical situation was carried out using laboratory tests of specific blood parameters. Results: The decrease in antibody titters, due to the action of the immunosuppressants used in association with the TPE sessions, in addition to the clear clinical impact on the recovery of renal function, also made it possible to remove this interference and select the blood units more safely. Conclusion: It is essential to develop methods that identify and remove pathological substances that could interfere with the compatibility of units to be transfused and, therefore, with transfusion safety. https://revistas.rcaap.pt/millenium/article/view/36799laboratory interference; therapeutic plasmapheresis; crossmatch; transfusion
spellingShingle Luís Moura
Liliana Fonseca
Emanuel Rodrigues
Rui Lobo
Arnaldo Brito
Mariana Costa
The possible impact of pre-transfusion laboratory interference
Millenium
laboratory interference; therapeutic plasmapheresis; crossmatch; transfusion
title The possible impact of pre-transfusion laboratory interference
title_full The possible impact of pre-transfusion laboratory interference
title_fullStr The possible impact of pre-transfusion laboratory interference
title_full_unstemmed The possible impact of pre-transfusion laboratory interference
title_short The possible impact of pre-transfusion laboratory interference
title_sort possible impact of pre transfusion laboratory interference
topic laboratory interference; therapeutic plasmapheresis; crossmatch; transfusion
url https://revistas.rcaap.pt/millenium/article/view/36799
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