Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants
Objective·To analyze the imaging characteristics and diagnostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application to distinguishing between classic and aggressive variants of MCL.Methods·A retro...
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2024-12-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
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| Online Access: | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-12-1561.shtml |
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| author | REN Yixuan CHEN Cheng CAI Mingci CHEN Jiamin YANG Xinxin WANG Chao LIN Xiaozhu CHENG Shu JIANG Xufeng CHEN Dongxu |
| author_facet | REN Yixuan CHEN Cheng CAI Mingci CHEN Jiamin YANG Xinxin WANG Chao LIN Xiaozhu CHENG Shu JIANG Xufeng CHEN Dongxu |
| author_sort | REN Yixuan |
| collection | DOAJ |
| description | Objective·To analyze the imaging characteristics and diagnostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application to distinguishing between classic and aggressive variants of MCL.Methods·A retrospective analysis was conducted on the 18F-FDG PET/CT images and clinical data of 116 pathologically confirmed, newly diagnosed MCL patients. The imaging features of intra- and extra-nodal lesions were summarized. The accuracy of 18F-FDG PET/CT in diagnosing bone marrow and gastrointestinal involvement in MCL was evaluated. Furthermore, differences in 18F-FDG PET/CT findings and clinical characteristics between the classic and aggressive variants of MCL were analyzed.Results·Among the 116 patients, 100.0% showed positive findings on 18F-FDG PET/CT, with 99.1% exhibiting abnormal lymph nodes and 85.3% having extra-nodal involvement. The most common extra-nodal sites were the spleen, Waldeyer's ring, bone marrow, and gastrointestinal tract. Compared with bone marrow aspiration results, the sensitivity, specificity, and accuracy of 18F-FDG PET/CT for detecting bone marrow involvement in MCL were 43.4%, 91.5%, and 66.0%, respectively. When compared with endoscopic biopsy results, the sensitivity of 18F-FDG PET/CT for detecting gastric and intestinal involvement was 100.0% and 94.1%, respectively, with specificity of 75.0% and 100.0%, and accuracy of 92.9% and 94.7%, respectively. There were significant differences in the highest maximum standardized uptake value (SUVmax) and Ki-67 index between the classic and aggressive variants of MCL, with SUVmax positively correlated with Ki-67 index. By using SUVmax > 10.4 as the diagnostic threshold, the sensitivity and specificity for differentiating between the classic and aggressive variants of MCL were 73.9% and 77.4%, respectively, with an AUC value of 0.797.Conclusion·18F-FDG PET/CT demonstrates a high detection rate for both intra- and extra-nodal lesions in MCL patients. It exhibits high specificity in diagnosing bone marrow involvement and high sensitivity and specificity in diagnosing gastrointestinal involvement, providing reliable non-invasive diagnostic information for MCL bone marrow and gastrointestinal involvement. However, it is not a substitute for pathological examination. Additionally, the positive correlation between SUVmax and Ki-67 index allows SUVmax to effectively differentiate between the classic and aggressive variants of MCL, with a higher SUVmax (>10.4) indicating a higher likelihood of the aggressive variant. These findings have clinical implications for treatment planning and prognosis assessment. |
| format | Article |
| id | doaj-art-76583abb0baf44e7baad8cc6431f3d06 |
| institution | Kabale University |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
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| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-76583abb0baf44e7baad8cc6431f3d062025-01-08T05:52:54ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152024-12-0144121561156910.3969/j.issn.1674-8115.2024.12.0091674-8115（2024）12-1561-09Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variantsREN Yixuan0CHEN Cheng1CAI Mingci2CHEN Jiamin3YANG Xinxin4WANG Chao5LIN Xiaozhu6CHENG Shu7JIANG Xufeng8CHEN Dongxu9Department of Nuclear Medicine, Wuxi Xinwu District Xinrui Hospital, Wuxi214000, ChinaDepartment of Nuclear Medicine, Wuxi Xinwu District Xinrui Hospital, Wuxi214000, ChinaDepartment of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaDepartment of Nuclear Medicine, Wuxi Xinwu District Xinrui Hospital, Wuxi214000, ChinaDepartment of Nuclear Medicine, Wuxi Xinwu District Xinrui Hospital, Wuxi214000, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaDepartment of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200025, ChinaDepartment of Nuclear Medicine, Wuxi Xinwu District Xinrui Hospital, Wuxi214000, ChinaDepartment of Nuclear Medicine, Wuxi Xinwu District Xinrui Hospital, Wuxi214000, ChinaObjective·To analyze the imaging characteristics and diagnostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application to distinguishing between classic and aggressive variants of MCL.Methods·A retrospective analysis was conducted on the 18F-FDG PET/CT images and clinical data of 116 pathologically confirmed, newly diagnosed MCL patients. The imaging features of intra- and extra-nodal lesions were summarized. The accuracy of 18F-FDG PET/CT in diagnosing bone marrow and gastrointestinal involvement in MCL was evaluated. Furthermore, differences in 18F-FDG PET/CT findings and clinical characteristics between the classic and aggressive variants of MCL were analyzed.Results·Among the 116 patients, 100.0% showed positive findings on 18F-FDG PET/CT, with 99.1% exhibiting abnormal lymph nodes and 85.3% having extra-nodal involvement. The most common extra-nodal sites were the spleen, Waldeyer's ring, bone marrow, and gastrointestinal tract. Compared with bone marrow aspiration results, the sensitivity, specificity, and accuracy of 18F-FDG PET/CT for detecting bone marrow involvement in MCL were 43.4%, 91.5%, and 66.0%, respectively. When compared with endoscopic biopsy results, the sensitivity of 18F-FDG PET/CT for detecting gastric and intestinal involvement was 100.0% and 94.1%, respectively, with specificity of 75.0% and 100.0%, and accuracy of 92.9% and 94.7%, respectively. There were significant differences in the highest maximum standardized uptake value (SUVmax) and Ki-67 index between the classic and aggressive variants of MCL, with SUVmax positively correlated with Ki-67 index. By using SUVmax > 10.4 as the diagnostic threshold, the sensitivity and specificity for differentiating between the classic and aggressive variants of MCL were 73.9% and 77.4%, respectively, with an AUC value of 0.797.Conclusion·18F-FDG PET/CT demonstrates a high detection rate for both intra- and extra-nodal lesions in MCL patients. It exhibits high specificity in diagnosing bone marrow involvement and high sensitivity and specificity in diagnosing gastrointestinal involvement, providing reliable non-invasive diagnostic information for MCL bone marrow and gastrointestinal involvement. However, it is not a substitute for pathological examination. Additionally, the positive correlation between SUVmax and Ki-67 index allows SUVmax to effectively differentiate between the classic and aggressive variants of MCL, with a higher SUVmax (>10.4) indicating a higher likelihood of the aggressive variant. These findings have clinical implications for treatment planning and prognosis assessment.https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-12-1561.shtmlmantle cell lymphoma (mcl)18f-fluorodeoxyglucose positron emission tomography-computed tomography (18f-fdg pet/ct)aggressive variant |
| spellingShingle | REN Yixuan CHEN Cheng CAI Mingci CHEN Jiamin YANG Xinxin WANG Chao LIN Xiaozhu CHENG Shu JIANG Xufeng CHEN Dongxu Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants Shanghai Jiaotong Daxue xuebao. Yixue ban mantle cell lymphoma (mcl) 18f-fluorodeoxyglucose positron emission tomography-computed tomography (18f-fdg pet/ct) aggressive variant |
| title | Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants |
| title_full | Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants |
| title_fullStr | Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants |
| title_full_unstemmed | Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants |
| title_short | Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants |
| title_sort | research on the characteristics of 18f fdg pet ct in mantle cell lymphoma and the discrimination between cellular morphological variants |
| topic | mantle cell lymphoma (mcl) 18f-fluorodeoxyglucose positron emission tomography-computed tomography (18f-fdg pet/ct) aggressive variant |
| url | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-12-1561.shtml |
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