Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP‐1c Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism

Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP‐1c Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism

Abstract Glycerol kinase (GK) participates in triglyceride (TG) synthesis by catalyzing glycerol metabolism. Whether GK contributes to nonalcoholic fatty liver (NAFL) is unclear. The expression of hepatic Gk is found to be increased in diet‐induced and genetic mouse models of NAFL and is positively...

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Main Authors: Shuyu Ouyang, Shu Zhuo, Mengmei Yang, Tengfei Zhu, Shuting Yu, Yu Li, Hao Ying, Yingying Le
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
de novo lipogenesis
glycerol kinase
nonalcoholic fatty liver disease
SREBP‐1c
triglyceride
Online Access:https://doi.org/10.1002/advs.202401311
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