Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia

Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia

Abstract Background The homeobox (HOX) genes especially for HOXA cluster play crucial roles in leukemogenesis. HOXA overexpression caused by genetic alterations, such as KMT2A rearrangements, NUP98- fusions and FLT3-ITD mutations, is frequently identified in AML. However, very few studies determined...

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Bibliographic Details
Main Authors: Fei Xie, Ting-juan Zhang, Xin-long Zhang, Zi-jun Xu, Liang Qiao, Yun Wang, Yang-jing Zhao, Jun Qian, Jing-dong Zhou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
HOXA
HOXA9
Methylation
Regulation
Prognosis
AML
Online Access:https://doi.org/10.1186/s12885-025-13633-y
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