Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials
Background: Earlier studies about the influence of vitamin D (Vit D) supplementation on patients with inflammatory bowel disease (IBD) reported inconsistent results. Current comprehensive systematic review and meta-analysis was conducted to assess the effect of Vit D supplementation on clinical and...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-11-01
|
| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpvm.ijpvm_133_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846139266908815360 |
|---|---|
| author | Reza Ramezani Parivash Ghorbaninejad Masoumeh Eslahi Leila Sheikhi Fatemeh Abbasi Mohaddeseh Hasanzadeh Saba Mohammadpour Alireza Milajerdi |
| author_facet | Reza Ramezani Parivash Ghorbaninejad Masoumeh Eslahi Leila Sheikhi Fatemeh Abbasi Mohaddeseh Hasanzadeh Saba Mohammadpour Alireza Milajerdi |
| author_sort | Reza Ramezani |
| collection | DOAJ |
| description | Background:
Earlier studies about the influence of vitamin D (Vit D) supplementation on patients with inflammatory bowel disease (IBD) reported inconsistent results. Current comprehensive systematic review and meta-analysis was conducted to assess the effect of Vit D supplementation on clinical and subclinical factors in patients with IBD.
Methods:
PubMed, Scopus, and Web of Science databases were searched for relevant randomized controlled trials (RCTs) on the effect of Vit D supplementation in IBD patients, published up to March 2023. Data were analyzed by the random-effect model. Heterogeneity was assessed by Cochran’s Q test and I-square (I2) statistic. The mean differences (MDs) were calculated as the summary effect size.
Results:
We included nine related articles, and our findings indicated that vitamin D administration increased serum vitamin D levels compared to placebo (weighted mean difference (WMD): 12.08; 95% confidence interval (95% CI): 9.06, 15.09; I2 = 97.01%; P < 0.001) in IBD patients. However, it had no significant influence on disease activity (standardized mean difference (SMD): 0.27; 95% CI: -0.42, 0.95; I2 = 91.7%; P < 0.001) or serum levels of C-reactive protein (CRP) (WMD: -1.42; 95% CI: -3.90, 1.06; I2 = 41.9%; P = 0.262).
Conclusions:
Current meta-analysis showed a significant effect of Vit D supplementation on increasing serum cholecalciferol. However, no significant effects of Vit D supplementation on the disease activity and serum levels of CRP were seen. Further studies are needed to expand current knowledge in this issue and found a significant increment in serum 25-hydroxy cholecalciferol concentrations following Vit D supplementation in IBD patients. |
| format | Article |
| id | doaj-art-75d27b4d45b44e89a322910e6966ea9d |
| institution | Kabale University |
| issn | 2008-7802 2008-8213 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj-art-75d27b4d45b44e89a322910e6966ea9d2024-12-06T11:11:03ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132024-11-0115656510.4103/ijpvm.ijpvm_133_23Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical TrialsReza RamezaniParivash GhorbaninejadMasoumeh EslahiLeila SheikhiFatemeh AbbasiMohaddeseh HasanzadehSaba MohammadpourAlireza MilajerdiBackground: Earlier studies about the influence of vitamin D (Vit D) supplementation on patients with inflammatory bowel disease (IBD) reported inconsistent results. Current comprehensive systematic review and meta-analysis was conducted to assess the effect of Vit D supplementation on clinical and subclinical factors in patients with IBD. Methods: PubMed, Scopus, and Web of Science databases were searched for relevant randomized controlled trials (RCTs) on the effect of Vit D supplementation in IBD patients, published up to March 2023. Data were analyzed by the random-effect model. Heterogeneity was assessed by Cochran’s Q test and I-square (I2) statistic. The mean differences (MDs) were calculated as the summary effect size. Results: We included nine related articles, and our findings indicated that vitamin D administration increased serum vitamin D levels compared to placebo (weighted mean difference (WMD): 12.08; 95% confidence interval (95% CI): 9.06, 15.09; I2 = 97.01%; P < 0.001) in IBD patients. However, it had no significant influence on disease activity (standardized mean difference (SMD): 0.27; 95% CI: -0.42, 0.95; I2 = 91.7%; P < 0.001) or serum levels of C-reactive protein (CRP) (WMD: -1.42; 95% CI: -3.90, 1.06; I2 = 41.9%; P = 0.262). Conclusions: Current meta-analysis showed a significant effect of Vit D supplementation on increasing serum cholecalciferol. However, no significant effects of Vit D supplementation on the disease activity and serum levels of CRP were seen. Further studies are needed to expand current knowledge in this issue and found a significant increment in serum 25-hydroxy cholecalciferol concentrations following Vit D supplementation in IBD patients.https://journals.lww.com/10.4103/ijpvm.ijpvm_133_23cholecalciferolinflammatory bowel diseasesmeta-analysisvitamin d |
| spellingShingle | Reza Ramezani Parivash Ghorbaninejad Masoumeh Eslahi Leila Sheikhi Fatemeh Abbasi Mohaddeseh Hasanzadeh Saba Mohammadpour Alireza Milajerdi Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials International Journal of Preventive Medicine cholecalciferol inflammatory bowel diseases meta-analysis vitamin d |
| title | Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials |
| title_full | Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials |
| title_fullStr | Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials |
| title_full_unstemmed | Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials |
| title_short | Effects of Vitamin D Supplementation on Serum 25-Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta-Analysis of Randomized Clinical Trials |
| title_sort | effects of vitamin d supplementation on serum 25 hydroxy cholecalciferol in inflammatory bowel diseases a meta analysis of randomized clinical trials |
| topic | cholecalciferol inflammatory bowel diseases meta-analysis vitamin d |
| url | https://journals.lww.com/10.4103/ijpvm.ijpvm_133_23 |
| work_keys_str_mv | AT rezaramezani effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT parivashghorbaninejad effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT masoumeheslahi effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT leilasheikhi effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT fatemehabbasi effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT mohaddesehhasanzadeh effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT sabamohammadpour effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials AT alirezamilajerdi effectsofvitamindsupplementationonserum25hydroxycholecalciferolininflammatoryboweldiseasesametaanalysisofrandomizedclinicaltrials |