Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria
IntroductionDysarthria is a motor speech disorder frequently associated with subcortical damage. However, the precise roles of the subcortical nuclei, particularly the basal ganglia and thalamus, in the speech production process remain poorly understood.MethodsThe present study aimed to better under...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1455085/full |
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| author | Juan Liu Juan Liu Rukiye Ruzi Chuyao Jian Qiuyu Wang Shuzhi Zhao Manwa L. Ng Shaofeng Zhao Lan Wang Nan Yan |
| author_facet | Juan Liu Juan Liu Rukiye Ruzi Chuyao Jian Qiuyu Wang Shuzhi Zhao Manwa L. Ng Shaofeng Zhao Lan Wang Nan Yan |
| author_sort | Juan Liu |
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| description | IntroductionDysarthria is a motor speech disorder frequently associated with subcortical damage. However, the precise roles of the subcortical nuclei, particularly the basal ganglia and thalamus, in the speech production process remain poorly understood.MethodsThe present study aimed to better understand their roles by mapping neuroimaging, behavioral, and speech data obtained from subacute stroke patients with subcortical lesions. Multivariate lesion-symptom mapping and voxel-based morphometry methods were employed to correlate lesions in the basal ganglia and thalamus with speech production, with emphases on linguistic processing and articulation.ResultsThe present findings revealed that the left thalamus and putamen are significantly correlated with concept preparation (r = 0.64, p < 0.01) and word retrieval (r = 0.56, p < 0.01). As the difficulty of the behavioral tasks increased, the influence of cognitive factors on early linguistic processing gradually intensified. The globus pallidus and caudate nucleus were found to significantly impact the movements of the larynx (r = 0.63, p < 0.01) and tongue (r = 0.59, p = 0.01). These insights underscore the complex and interconnected roles of the basal ganglia and thalamus in the intricate processes of speech production. The lateralization and hierarchical organization of each nucleus are crucial to their contributions to these speech functions.DiscussionThe present study provides a nuanced understanding of how lesions in the basal ganglia and thalamus impact various stages of speech production, thereby enhancing our understanding of the subcortical neuromechanisms underlying dysarthria. The findings could also contribute to the identification of multimodal assessment indicators, which could aid in the precise evaluation and personalized treatment of speech impairments. |
| format | Article |
| id | doaj-art-75cdae6530934ae68e65c3549314d70a |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-75cdae6530934ae68e65c3549314d70a2025-01-07T06:40:23ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-01-011810.3389/fnins.2024.14550851455085Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthriaJuan Liu0Juan Liu1Rukiye Ruzi2Chuyao Jian3Qiuyu Wang4Shuzhi Zhao5Manwa L. Ng6Shaofeng Zhao7Lan Wang8Nan Yan9Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaGuangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Radiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaGuangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaSpeech Science Laboratory, Faculty of Education, University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaGuangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaGuangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaIntroductionDysarthria is a motor speech disorder frequently associated with subcortical damage. However, the precise roles of the subcortical nuclei, particularly the basal ganglia and thalamus, in the speech production process remain poorly understood.MethodsThe present study aimed to better understand their roles by mapping neuroimaging, behavioral, and speech data obtained from subacute stroke patients with subcortical lesions. Multivariate lesion-symptom mapping and voxel-based morphometry methods were employed to correlate lesions in the basal ganglia and thalamus with speech production, with emphases on linguistic processing and articulation.ResultsThe present findings revealed that the left thalamus and putamen are significantly correlated with concept preparation (r = 0.64, p < 0.01) and word retrieval (r = 0.56, p < 0.01). As the difficulty of the behavioral tasks increased, the influence of cognitive factors on early linguistic processing gradually intensified. The globus pallidus and caudate nucleus were found to significantly impact the movements of the larynx (r = 0.63, p < 0.01) and tongue (r = 0.59, p = 0.01). These insights underscore the complex and interconnected roles of the basal ganglia and thalamus in the intricate processes of speech production. The lateralization and hierarchical organization of each nucleus are crucial to their contributions to these speech functions.DiscussionThe present study provides a nuanced understanding of how lesions in the basal ganglia and thalamus impact various stages of speech production, thereby enhancing our understanding of the subcortical neuromechanisms underlying dysarthria. The findings could also contribute to the identification of multimodal assessment indicators, which could aid in the precise evaluation and personalized treatment of speech impairments.https://www.frontiersin.org/articles/10.3389/fnins.2024.1455085/fullsubacute strokedysarthriaspeech productionlinguistic processingarticulationbasal ganglia |
| spellingShingle | Juan Liu Juan Liu Rukiye Ruzi Chuyao Jian Qiuyu Wang Shuzhi Zhao Manwa L. Ng Shaofeng Zhao Lan Wang Nan Yan Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria Frontiers in Neuroscience subacute stroke dysarthria speech production linguistic processing articulation basal ganglia |
| title | Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria |
| title_full | Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria |
| title_fullStr | Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria |
| title_full_unstemmed | Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria |
| title_short | Mapping subcortical brain lesions, behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria |
| title_sort | mapping subcortical brain lesions behavioral and acoustic analysis for early assessment of subacute stroke patients with dysarthria |
| topic | subacute stroke dysarthria speech production linguistic processing articulation basal ganglia |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1455085/full |
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