The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease
The gut mycobiome significantly affects host health and immunity. However, most studies have focused on symbiotic bacteria in the gut microbiome, whereas less attention has been given to symbiotic fungi. Although fungi constitute only 0.01%–0.1% of the gut microbiome, their larger size and unique im...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2440111 |
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| author | Hui Huang Qiurong Wang Ying Yang Wei Zhong Feng He Jun Li |
| author_facet | Hui Huang Qiurong Wang Ying Yang Wei Zhong Feng He Jun Li |
| author_sort | Hui Huang |
| collection | DOAJ |
| description | The gut mycobiome significantly affects host health and immunity. However, most studies have focused on symbiotic bacteria in the gut microbiome, whereas less attention has been given to symbiotic fungi. Although fungi constitute only 0.01%–0.1% of the gut microbiome, their larger size and unique immunoregulatory functions make them significant. Factors like diet, antimicrobials use, and age can disrupt the fungal community, leading to dysbiosis. Fungal-bacterial-host immune interactions are critical in maintaining gut homeostasis, with fungi playing a role in mediating immune responses such as Th17 cell activation. This review highlights methods for studying gut fungi, the composition and influencing factors of the gut mycobiome, and its potential in therapeutic interventions for intestinal and hepatic diseases. We aim to provide new insights into the underexplored role of gut fungi in human health. |
| format | Article |
| id | doaj-art-75c72b16ef3541f8a6e6109b66a7fdea |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-75c72b16ef3541f8a6e6109b66a7fdea2024-12-16T07:46:32ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2440111The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and diseaseHui Huang0Qiurong Wang1Ying Yang2Wei Zhong3Feng He4Jun Li5Department of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. ChinaDepartment of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. ChinaDepartment of Gastroenterology, Sichuan Fifth People’s Hospital, Chengdu, ChinaDepartment of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. ChinaDepartment of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. ChinaDepartment of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. ChinaThe gut mycobiome significantly affects host health and immunity. However, most studies have focused on symbiotic bacteria in the gut microbiome, whereas less attention has been given to symbiotic fungi. Although fungi constitute only 0.01%–0.1% of the gut microbiome, their larger size and unique immunoregulatory functions make them significant. Factors like diet, antimicrobials use, and age can disrupt the fungal community, leading to dysbiosis. Fungal-bacterial-host immune interactions are critical in maintaining gut homeostasis, with fungi playing a role in mediating immune responses such as Th17 cell activation. This review highlights methods for studying gut fungi, the composition and influencing factors of the gut mycobiome, and its potential in therapeutic interventions for intestinal and hepatic diseases. We aim to provide new insights into the underexplored role of gut fungi in human health.https://www.tandfonline.com/doi/10.1080/19490976.2024.2440111Gut mycobiomecommensal fungifungal dysbiosisfungal‒bacterial interactionimmune response |
| spellingShingle | Hui Huang Qiurong Wang Ying Yang Wei Zhong Feng He Jun Li The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease Gut Microbes Gut mycobiome commensal fungi fungal dysbiosis fungal‒bacterial interaction immune response |
| title | The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease |
| title_full | The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease |
| title_fullStr | The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease |
| title_full_unstemmed | The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease |
| title_short | The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease |
| title_sort | mycobiome as integral part of the gut microbiome crucial role of symbiotic fungi in health and disease |
| topic | Gut mycobiome commensal fungi fungal dysbiosis fungal‒bacterial interaction immune response |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2440111 |
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