The Novel Use of Daratumumab in the Treatment of Refractory Autoimmune Pulmonary Alveolar Proteinosis

The Novel Use of Daratumumab in the Treatment of Refractory Autoimmune Pulmonary Alveolar Proteinosis

ABSTRACT Autoimmune pulmonary alveolar proteinosis (aPAP) is caused by circulating anti‐granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) auto‐antibodies that impair alveolar macrophage and neutrophil function. Macrophage dysfunction leads to accumulation of protein‐ and lipid‐rich surfactan...

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Bibliographic Details
Main Authors: April Strong, Ying Sun, David Pilcher, Zane Kaplan, Rob G. Stirling
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Respirology Case Reports
Subjects:
anti‐GM‐CSF
autoimmune
daratumumab
pulmonary alveolar proteinosis
Online Access:https://doi.org/10.1002/rcr2.70246
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