Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions
Depression represents a complex mental health problem worldwide, affecting millions of people and causing significant societal and personal distress. A plethora of evidence has emerged indicating an important role of gender dimorphism in depression, with prevalence rates, symptomatology, and treatme...
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| Format: | Article |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2024-01-01
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| Series: | Arhiv za farmaciju |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632406758N.pdf |
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| _version_ | 1841554332210692096 |
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| author | Nedeljković Jelena Stanić Dušanka Petrović Jelena Ivanović Ana Ilić Miloš Nikolašević-Stojković Gorana Pejušković Bojana Pešić Vesna |
| author_facet | Nedeljković Jelena Stanić Dušanka Petrović Jelena Ivanović Ana Ilić Miloš Nikolašević-Stojković Gorana Pejušković Bojana Pešić Vesna |
| author_sort | Nedeljković Jelena |
| collection | DOAJ |
| description | Depression represents a complex mental health problem worldwide, affecting millions of people and causing significant societal and personal distress. A plethora of evidence has emerged indicating an important role of gender dimorphism in depression, with prevalence rates, symptomatology, and treatment responses differing between men and women. Women are generally more likely to suffer from depression, which is often attributed to hormonal influences, psychosocial stressors, and gender-specific coping mechanisms. In contrast, men may exhibit different depressive patterns, characterized by externalizing behaviors and higher suicide rates. Neurobiological studies highlight gender-specific differences in brain structure and function, as well as in neurotransmitter systems, which may impact treatment efficacy and response variability. While conventional pharmacotherapy remains pivotal, personalized approaches that integrate psychotherapeutic modalities such as cognitive-behavioral therapy and mindfulness-based interventions have increased in recent years. However, gender differences in treatment outcomes emphasize the need for differentiated, gender-sensitive clinical strategies. This review summarizes the current literature to highlight the complexity of depression and the importance of tailoring interventions to optimize clinical outcomes in diverse populations. |
| format | Article |
| id | doaj-art-7593f5430078459fabd0715855c9c701 |
| institution | Kabale University |
| issn | 0004-1963 2217-8767 |
| language | srp |
| publishDate | 2024-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj-art-7593f5430078459fabd0715855c9c7012025-01-08T15:12:31ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672024-01-0174675877310.5937/arhfarm74-541510004-19632406758NSexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributionsNedeljković Jelena0Stanić Dušanka1https://orcid.org/0000-0002-4494-5554Petrović Jelena2https://orcid.org/0000-0002-1821-1362Ivanović Ana3Ilić Miloš4Nikolašević-Stojković Gorana5Pejušković Bojana6https://orcid.org/0000-0001-7879-5745Pešić Vesna7https://orcid.org/0000-0002-1951-7291University of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaInstitute of Mental Health, Clinical Department for Crisis Intervention and Affective Disorders, Head, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Physiology, Belgrade, SerbiaDepression represents a complex mental health problem worldwide, affecting millions of people and causing significant societal and personal distress. A plethora of evidence has emerged indicating an important role of gender dimorphism in depression, with prevalence rates, symptomatology, and treatment responses differing between men and women. Women are generally more likely to suffer from depression, which is often attributed to hormonal influences, psychosocial stressors, and gender-specific coping mechanisms. In contrast, men may exhibit different depressive patterns, characterized by externalizing behaviors and higher suicide rates. Neurobiological studies highlight gender-specific differences in brain structure and function, as well as in neurotransmitter systems, which may impact treatment efficacy and response variability. While conventional pharmacotherapy remains pivotal, personalized approaches that integrate psychotherapeutic modalities such as cognitive-behavioral therapy and mindfulness-based interventions have increased in recent years. However, gender differences in treatment outcomes emphasize the need for differentiated, gender-sensitive clinical strategies. This review summarizes the current literature to highlight the complexity of depression and the importance of tailoring interventions to optimize clinical outcomes in diverse populations.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632406758N.pdfdepressiongender dimorphismsex differencesantidepressants |
| spellingShingle | Nedeljković Jelena Stanić Dušanka Petrović Jelena Ivanović Ana Ilić Miloš Nikolašević-Stojković Gorana Pejušković Bojana Pešić Vesna Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions Arhiv za farmaciju depression gender dimorphism sex differences antidepressants |
| title | Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions |
| title_full | Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions |
| title_fullStr | Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions |
| title_full_unstemmed | Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions |
| title_short | Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions |
| title_sort | sexual dimorphism in the response to antidepressant therapy biological basis and clinical implications declaration of competing interests author contributions |
| topic | depression gender dimorphism sex differences antidepressants |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632406758N.pdf |
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