Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire
Topical steroid withdrawal (TSW) is described as an adverse reaction to topical glucocorticoids (TGCs). A pathophysiological mechanism has not been identified. There are no diagnostic criteria. The aim was to describe patient-reported characteristics of TSW in atopic dermatitis (AD). An observationa...
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/40187 |
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| author | Mikael Alsterholm Maja af Klinteberg Sophie Vrang Gunnthorunn Sigurdardottir MariHelen Sandström Falk Alexander Shayesteh |
| author_facet | Mikael Alsterholm Maja af Klinteberg Sophie Vrang Gunnthorunn Sigurdardottir MariHelen Sandström Falk Alexander Shayesteh |
| author_sort | Mikael Alsterholm |
| collection | DOAJ |
| description | Topical steroid withdrawal (TSW) is described as an adverse reaction to topical glucocorticoids (TGCs). A pathophysiological mechanism has not been identified. There are no diagnostic criteria. The aim was to describe patient-reported characteristics of TSW in atopic dermatitis (AD). An observational cross-sectional study was performed by posting a questionnaire for participants, aged ≥18 years, reporting both AD and TSW, in a Swedish TSW-themed Facebook group during 4 weeks in 2023. The questionnaire was accessed by 98 participants, with 82 completing it. Most were female (95%), 18–39 years old (74%), self-diagnosed with TSW (84%), and reported current symptoms of AD and TSW. They defined TSW as dependency on TGCs and adverse reactions to their use. Erythema, desquamation, dryness, and oozing affecting the face, neck, and upper extremities were the most reported signs. Pruritus, sleep disturbance, and signs of anxiety and depression were the most reported symptoms. Recurring episodes of manifestations attributed to TSW were reported by 60%. The personal trigger factor was believed to be TGCs by 93%, and 33% also identified oral glucocorticoids. TGCs were currently used by 21%. Self-reported manifestations of TSW are similar to those of AD but appeared to be distinguishable for the participants and caused considerable morbidity.
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| format | Article |
| id | doaj-art-757f9f24aad64e818593641cc0344c53 |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-757f9f24aad64e818593641cc0344c532025-01-03T08:46:04ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-01-0110510.2340/actadv.v105.40187Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media QuestionnaireMikael Alsterholm0Maja af Klinteberg1Sophie Vrang2Gunnthorunn Sigurdardottir3MariHelen Sandström Falk4Alexander Shayesteh5Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, SwedenPatient organisation Atopikerna, the Swedish Asthma and Allergy Association, Stockholm, SwedenDepartment of Dermatology and Venereology in Östergötland, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenVasakliniken Dermatology Clinic, Gothenburg, SwedenDepartment of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, SwedenTopical steroid withdrawal (TSW) is described as an adverse reaction to topical glucocorticoids (TGCs). A pathophysiological mechanism has not been identified. There are no diagnostic criteria. The aim was to describe patient-reported characteristics of TSW in atopic dermatitis (AD). An observational cross-sectional study was performed by posting a questionnaire for participants, aged ≥18 years, reporting both AD and TSW, in a Swedish TSW-themed Facebook group during 4 weeks in 2023. The questionnaire was accessed by 98 participants, with 82 completing it. Most were female (95%), 18–39 years old (74%), self-diagnosed with TSW (84%), and reported current symptoms of AD and TSW. They defined TSW as dependency on TGCs and adverse reactions to their use. Erythema, desquamation, dryness, and oozing affecting the face, neck, and upper extremities were the most reported signs. Pruritus, sleep disturbance, and signs of anxiety and depression were the most reported symptoms. Recurring episodes of manifestations attributed to TSW were reported by 60%. The personal trigger factor was believed to be TGCs by 93%, and 33% also identified oral glucocorticoids. TGCs were currently used by 21%. Self-reported manifestations of TSW are similar to those of AD but appeared to be distinguishable for the participants and caused considerable morbidity. https://medicaljournalssweden.se/actadv/article/view/40187Atopic DermatitisRed Skin SyndromeTopical Steroid AddictionTopical Steroid WithdrawalTopical Steroid Withdrawal Syndrome |
| spellingShingle | Mikael Alsterholm Maja af Klinteberg Sophie Vrang Gunnthorunn Sigurdardottir MariHelen Sandström Falk Alexander Shayesteh Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire Acta Dermato-Venereologica Atopic Dermatitis Red Skin Syndrome Topical Steroid Addiction Topical Steroid Withdrawal Topical Steroid Withdrawal Syndrome |
| title | Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire |
| title_full | Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire |
| title_fullStr | Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire |
| title_full_unstemmed | Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire |
| title_short | Topical Steroid Withdrawal in Atopic Dermatitis: Patient-reported Characterization from a Swedish Social Media Questionnaire |
| title_sort | topical steroid withdrawal in atopic dermatitis patient reported characterization from a swedish social media questionnaire |
| topic | Atopic Dermatitis Red Skin Syndrome Topical Steroid Addiction Topical Steroid Withdrawal Topical Steroid Withdrawal Syndrome |
| url | https://medicaljournalssweden.se/actadv/article/view/40187 |
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