Progress on the mechanism of action of emodin against breast cancer cells
At present, the role of active ingredients of traditional Chinese medicine in tumor therapy has gradually attracted people's attention, and anthraquinones, which are structurally similar to adriamycin and epirubicin, are one of the hotspots of research. Emodin (1,3,8-trihydroxy-6-methylanthraqu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024146592 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846167118923431936 |
|---|---|
| author | Ruoqing Chen Hairong Zhang Xue Zhao Lin Zhu XiaoYu Zhang Yuning Ma Lei Xia |
| author_facet | Ruoqing Chen Hairong Zhang Xue Zhao Lin Zhu XiaoYu Zhang Yuning Ma Lei Xia |
| author_sort | Ruoqing Chen |
| collection | DOAJ |
| description | At present, the role of active ingredients of traditional Chinese medicine in tumor therapy has gradually attracted people's attention, and anthraquinones, which are structurally similar to adriamycin and epirubicin, are one of the hotspots of research. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone compound isolated from rhubarb, Polygonum cuspidatum, and aloe vera. In recent years, emodin has received widespread attention for its remarkable anti-tumor effects, and its anti-breast cancer effects are manifested as induction of apoptosis, inhibition of tumor cell proliferation, inhibition of invasion and metastasis of tumor cells, and anti-tumor drug resistance. Moreover, emodin can act against multiple types of breast cancer cells by acting on different targets. In this paper, we reviewed the latest research progress on the anti-breast cancer effects of emodin and its anti-tumor mechanism, to provide reference and information for the treatment of breast cancer and the development of anti-tumor drugs. |
| format | Article |
| id | doaj-art-756dca2a852c450385e423f1eb68f8a7 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-756dca2a852c450385e423f1eb68f8a72024-11-15T06:12:22ZengElsevierHeliyon2405-84402024-11-011021e38628Progress on the mechanism of action of emodin against breast cancer cellsRuoqing Chen0Hairong Zhang1Xue Zhao2Lin Zhu3XiaoYu Zhang4Yuning Ma5Lei Xia6School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR ChinaDepartment of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Shandong University, Jinan, 250031, PR ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR ChinaSchool of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR ChinaSchool of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Corresponding author.Department of Pathology, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Corresponding author. Department of Pathology, Shandong University of Traditional Chinese Medicine, 250031, Jinan, PR China.At present, the role of active ingredients of traditional Chinese medicine in tumor therapy has gradually attracted people's attention, and anthraquinones, which are structurally similar to adriamycin and epirubicin, are one of the hotspots of research. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural anthraquinone compound isolated from rhubarb, Polygonum cuspidatum, and aloe vera. In recent years, emodin has received widespread attention for its remarkable anti-tumor effects, and its anti-breast cancer effects are manifested as induction of apoptosis, inhibition of tumor cell proliferation, inhibition of invasion and metastasis of tumor cells, and anti-tumor drug resistance. Moreover, emodin can act against multiple types of breast cancer cells by acting on different targets. In this paper, we reviewed the latest research progress on the anti-breast cancer effects of emodin and its anti-tumor mechanism, to provide reference and information for the treatment of breast cancer and the development of anti-tumor drugs.http://www.sciencedirect.com/science/article/pii/S2405844024146592EmodinTumorMolecular mechanismBreast cancerHerb |
| spellingShingle | Ruoqing Chen Hairong Zhang Xue Zhao Lin Zhu XiaoYu Zhang Yuning Ma Lei Xia Progress on the mechanism of action of emodin against breast cancer cells Heliyon Emodin Tumor Molecular mechanism Breast cancer Herb |
| title | Progress on the mechanism of action of emodin against breast cancer cells |
| title_full | Progress on the mechanism of action of emodin against breast cancer cells |
| title_fullStr | Progress on the mechanism of action of emodin against breast cancer cells |
| title_full_unstemmed | Progress on the mechanism of action of emodin against breast cancer cells |
| title_short | Progress on the mechanism of action of emodin against breast cancer cells |
| title_sort | progress on the mechanism of action of emodin against breast cancer cells |
| topic | Emodin Tumor Molecular mechanism Breast cancer Herb |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024146592 |
| work_keys_str_mv | AT ruoqingchen progressonthemechanismofactionofemodinagainstbreastcancercells AT hairongzhang progressonthemechanismofactionofemodinagainstbreastcancercells AT xuezhao progressonthemechanismofactionofemodinagainstbreastcancercells AT linzhu progressonthemechanismofactionofemodinagainstbreastcancercells AT xiaoyuzhang progressonthemechanismofactionofemodinagainstbreastcancercells AT yuningma progressonthemechanismofactionofemodinagainstbreastcancercells AT leixia progressonthemechanismofactionofemodinagainstbreastcancercells |