Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction

Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction

BackgroundAdenocarcinoma of the esophagogastric junction (AEGJ) is a highly aggressive tumor that frequently metastasizes to the liver. Understanding the cellular and molecular mechanisms that drive this process is essential for developing effective therapies.MethodsWe employed single-cell RNA seque...

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Bibliographic Details
Main Authors: Junrui Xu, Ussama Sadiq, Wangruizhi Zhao, Hengbo Xia, Yiwei Liu, Renquan Zhang, Aman Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
single-cell RNA sequencing
adenocarcinoma of esophagogastric junction
liver metastasis
tumor heterogeneity
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484234/full
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